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10 hits found for Martínez-Lumbreras

SASDM43 – RRM1-ZnF1 tandem domains of RNA-binding protein 5 (C191G mutant)

RNA-binding protein 5 (I107T, C191G) experimental SAS data
Sample: RNA-binding protein 5 (I107T, C191G) monomer, 14 kDa Homo sapiens protein
Buffer: 20 mM MES, 400 mM NaCl, 1 mM DTT, pH: 6.5
Experiment: SAXS data collected at BM29, ESRF on 2016 Sep 26
Structural basis for specific RNA recognition by the alternative splicing factor RBM5. Nat Commun 14(1):4233 (2023)
...Martínez-Lumbreras S, Bonnal S, Geerlof A, Stehle R, Simon B, Valcárcel J, Sattler M
RgGuinier 1.7 nm
Dmax 5.6 nm
VolumePorod 28 nm3

SASDM53 – RRM1-ZnF1-RRM2 triple domains of RNA-binding protein 5 (C191G mutant)

RNA Binding Motif protein 5 (I107T, C191G) experimental SAS data
RNA Binding Motif protein 5 (I107T, C191G) Kratky plot
Sample: RNA Binding Motif protein 5 (I107T, C191G) monomer, 26 kDa Homo sapiens protein
Buffer: 20 mM MES, 400 mM NaCl, 1 mM DTT, pH: 6.5
Experiment: SAXS data collected at Rigaku BioSAXS-1000, SFB 1035, Technische Universität München on 2017 Feb 9
Structural basis for specific RNA recognition by the alternative splicing factor RBM5. Nat Commun 14(1):4233 (2023)
...Martínez-Lumbreras S, Bonnal S, Geerlof A, Stehle R, Simon B, Valcárcel J, Sattler M
RgGuinier 2.3 nm
Dmax 7.8 nm
VolumePorod 36 nm3

SASDM63 – RRM1-ZnF1-RRM2 triple domains of RNA-binding protein 5 (C191G mutant) in complex with GGCU_12 RNA

RNA Binding Motif protein 5 (I107T, C191G)Caspase-2 derived RNA GGCU_12 experimental SAS data
OTHER model
Sample: RNA Binding Motif protein 5 (I107T, C191G) monomer, 26 kDa Homo sapiens protein
Caspase-2 derived RNA GGCU_12 monomer, 4 kDa RNA
Buffer: 20 mM MES, 100 mM NaCl, 1 mM DTT, pH: 6.5
Experiment: SAXS data collected at Rigaku BioSAXS-1000, SFB 1035, Technische Universität München on 2017 Mar 1
Structural basis for specific RNA recognition by the alternative splicing factor RBM5. Nat Commun 14(1):4233 (2023)
...Martínez-Lumbreras S, Bonnal S, Geerlof A, Stehle R, Simon B, Valcárcel J, Sattler M
RgGuinier 2.2 nm
Dmax 7.5 nm
VolumePorod 42 nm3

SASDDB6 – Small glutamine-rich tetratricopeptide repeat-containing protein alpha (full length; SGTA_FL)

Small glutamine-rich tetratricopeptide repeat-containing protein alpha full length experimental SAS data
Small glutamine-rich tetratricopeptide repeat-containing protein alpha full length Kratky plot
Sample: Small glutamine-rich tetratricopeptide repeat-containing protein alpha full length dimer, 68 kDa Homo sapiens protein
Buffer: 10 mM potassium phosphate, 100 mM NaCl, pH: 6
Experiment: SAXS data collected at EMBL P12, PETRA III on 2015 Jun 5
Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control. BMC Biol 16(1):76 (2018)
Martínez-Lumbreras S, Krysztofinska EM, Thapaliya A, Spilotros A, Matak-Vinkovic D, Salvadori E, Roboti P, Nyathi Y, Muench JH, Roessler MM, Svergun DI, High S, Isaacson RL
RgGuinier 4.2 nm

SASDDC6 – Small glutamine-rich tetratricopeptide repeat-containing protein alpha (N-terminal-TPR domains; SGTA_NT)

Small glutamine-rich tetratricopeptide repeat-containing protein alpha Nterminal-TPR domains experimental SAS data
Small glutamine-rich tetratricopeptide repeat-containing protein alpha Nterminal-TPR domains Kratky plot
Sample: Small glutamine-rich tetratricopeptide repeat-containing protein alpha Nterminal-TPR domains dimer, 47 kDa Homo sapiens protein
Buffer: 10 mM potassium phosphate, 100 mM NaCl, pH: 6
Experiment: SAXS data collected at EMBL P12, PETRA III on 2015 Jun 5
Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control. BMC Biol 16(1):76 (2018)
Martínez-Lumbreras S, Krysztofinska EM, Thapaliya A, Spilotros A, Matak-Vinkovic D, Salvadori E, Roboti P, Nyathi Y, Muench JH, Roessler MM, Svergun DI, High S, Isaacson RL
RgGuinier 3.6 nm

SASDP88 – N-terminal domain of S. cerevisiae eukaryotic initiation factor 4F subunit p150, eIF4G1 (Tif4631)

Eukaryotic initiation factor 4F subunit p150 experimental SAS data
Eukaryotic initiation factor 4F subunit p150 Kratky plot
Sample: Eukaryotic initiation factor 4F subunit p150 , 28 kDa Saccharomyces cerevisiae (strain … protein
Buffer: 25 mM potassium phosphate, 25 mM NaCl, pH: 6.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2018 Jul 14
eIF4G1 N-terminal intrinsically disordered domain is a multi-docking station for RNA, Pab1, Pub1, and self-assembly. Front Mol Biosci 9:986121 (2022)
...Martínez-Lumbreras S, Sibille N, Camero S, Bernadó P, Jiménez MÁ, Zorrilla S, Pérez-Cañadillas JM
RgGuinier 5.2 nm
Dmax 19.0 nm
VolumePorod 137 nm3

SASDSK7 – Tandem of WW domains of Pre-mRNA-processing factor 40 homolog A (PRPF40A)

Pre-mRNA-processing factor 40 homolog A experimental SAS data
Pre-mRNA-processing factor 40 homolog A Kratky plot
Sample: Pre-mRNA-processing factor 40 homolog A monomer, 11 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 100 mM NaCl, 0.5 mM DTT, pH: 6.5
Experiment: SAXS data collected at BM29, ESRF on 2020 Sep 19
Intramolecular autoinhibition regulates the selectivity of PRPF40A tandem WW domains for proline-rich motifs. Nat Commun 15(1):3888 (2024)
Martínez-Lumbreras S, Träger LK, Mulorz MM, Payr M, Dikaya V, Hipp C, König J, Sattler M
RgGuinier 2.0 nm
Dmax 6.4 nm
VolumePorod 17 nm3

SASDSL7 – Tandem WW domains of Pre-mRNA-processing factor 40 homolog A (PRPF40A) in complex with Splicing factor 1 (SF1) C-terminal proline repeat

Pre-mRNA-processing factor 40 homolog ASplicing factor 1 experimental SAS data
Pre-mRNA-processing factor 40 homolog A Splicing factor 1 Kratky plot
Sample: Pre-mRNA-processing factor 40 homolog A monomer, 11 kDa Homo sapiens protein
Splicing factor 1 monomer, 2 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 100 mM NaCl, 0.5 mM DTT, pH: 6.5
Experiment: SAXS data collected at BM29, ESRF on 2020 Sep 19
Intramolecular autoinhibition regulates the selectivity of PRPF40A tandem WW domains for proline-rich motifs. Nat Commun 15(1):3888 (2024)
Martínez-Lumbreras S, Träger LK, Mulorz MM, Payr M, Dikaya V, Hipp C, König J, Sattler M
RgGuinier 1.9 nm
Dmax 6.9 nm
VolumePorod 19 nm3

SASDUH4 – Tandem of WW domains of Pre-mRNA-processing factor 40 homolog A (PRPF40A) in HEPES buffer

Pre-mRNA-processing factor 40 homolog A experimental SAS data
Pre-mRNA-processing factor 40 homolog A Kratky plot
Sample: Pre-mRNA-processing factor 40 homolog A monomer, 11 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 100 mM NaCl, 1 mM DTT, pH: 6.6
Experiment: SAXS data collected at Rigaku BioSAXS-1000, Technische Universität München on 2024 Mar 8
Intramolecular autoinhibition regulates the selectivity of PRPF40A tandem WW domains for proline-rich motifs. Nat Commun 15(1):3888 (2024)
Martínez-Lumbreras S, Träger LK, Mulorz MM, Payr M, Dikaya V, Hipp C, König J, Sattler M
RgGuinier 2.0 nm
Dmax 6.3 nm
VolumePorod 18 nm3

SASDUJ4 – Tandem of WW domains of Pre-mRNA-processing factor 40 homolog A (PRPF40A) in complex with Splicing factor 1 (SF1) in HEPES buffer

Pre-mRNA-processing factor 40 homolog ASplicing factor 1 experimental SAS data
Pre-mRNA-processing factor 40 homolog A Splicing factor 1 Kratky plot
Sample: Pre-mRNA-processing factor 40 homolog A monomer, 11 kDa Homo sapiens protein
Splicing factor 1 monomer, 2 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 100 mM NaCl, 1 mM DTT, pH: 6.6
Experiment: SAXS data collected at Rigaku BioSAXS-1000, Technische Universität München on 2024 Mar 8
Intramolecular autoinhibition regulates the selectivity of PRPF40A tandem WW domains for proline-rich motifs. Nat Commun 15(1):3888 (2024)
Martínez-Lumbreras S, Träger LK, Mulorz MM, Payr M, Dikaya V, Hipp C, König J, Sattler M
RgGuinier 1.9 nm
Dmax 6.0 nm
VolumePorod 19 nm3