Small Angle Scattering Biological Data Bank SASBDB


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7 hits found for Cereblon-midi

SASDU52 – Cereblon-midi (CRBNmidi), an engineered Cereblon construct for crystallographic and biophysical studies, apo form

Sample:	Cereblon-midi monomer, 37 kDa protein
Buffer:	20 mM Hepes, 500 mM NaCl, 0.5 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2023 Mar 1

Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders Nature Communications 15(1) (2024)
Kroupova A, Spiteri V, Rutter Z, Furihata H, Darren D, Ramachandran S, Chakraborti S, Haubrich K, Pethe J, Gonzales D, Wijaya A, Rodriguez-Rios M, Sturbaut M, Lynch D, Farnaby W, Nakasone M, Zollman D...

R_g^Guinier	2.7	nm
D_max	8.6	nm
Volume^Porod	61	nm³

SASDU62 – Cereblon-midi (CRBNmidi), an engineered Cereblon construct for crystallographic and biophysical studies, bound to Mezigdomide

Cereblon-midimezigdomide experimental SAS data

Sample:	Cereblon-midi monomer, 37 kDa protein mezigdomide monomer, 1 kDa synthetic construct
Buffer:	20 mM Hepes, 500 mM NaCl, 0.5 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2023 Mar 1

R_g^Guinier	2.3	nm
D_max	7.3	nm
Volume^Porod	60	nm³

SASDU72 – Cereblon-midi (CRBNmidi), an engineered Cereblon construct for crystallographic and biophysical studies, bound to Pomalidomide

Cereblon-midipomalidomide experimental SAS data

Sample:	Cereblon-midi monomer, 37 kDa protein pomalidomide monomer, 0 kDa synthetic construct
Buffer:	20 mM Hepes, 500 mM NaCl, 0.5 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2023 Mar 1

R_g^Guinier	2.3	nm
D_max	6.9	nm
Volume^Porod	63	nm³

SASDU82 – Cereblon-midi (CRBNmidi), an engineered Cereblon construct for crystallographic and biophysical studies, bound to Iberdomide

Cereblon-midiIberdomide experimental SAS data

Sample:	Cereblon-midi monomer, 37 kDa protein Iberdomide monomer, 0 kDa synthetic construct
Buffer:	20 mM Hepes, 500 mM NaCl, 0.5 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2023 Mar 1

R_g^Guinier	2.4	nm
D_max	7.7	nm
Volume^Porod	68	nm³

SASDU92 – Cereblon-midi (CRBNmidi), an engineered Cereblon construct for crystallographic and biophysical studies, bound to Lenalidomide

Cereblon-midiLenalidomide experimental SAS data

Sample:	Cereblon-midi monomer, 37 kDa protein Lenalidomide monomer, 0 kDa synthetic construct
Buffer:	20 mM Hepes, 500 mM NaCl, 0.5 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2023 Mar 1

R_g^Guinier	2.2	nm
D_max	6.2	nm
Volume^Porod	59	nm³

SASDVN6 – Cereblon-midi (CRBNmidi), an engineered Cereblon construct for crystallographic and biophysical studies, bound to Boc-VcN

Sample:	Cereblon-midi monomer, 37 kDa synthetic construct protein
Buffer:	20 mM HEPES, 500 mM NaCl, 0.5 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 Jun 29

R_g^Guinier	2.3	nm
D_max	9.1	nm
Volume^Porod	63	nm³

SASDVP6 – Cereblon-midi (CRBNmidi), an engineered Cereblon construct for crystallographic and biophysical studies, bound to Boc-AcQ

Sample:	Cereblon-midi monomer, 37 kDa synthetic construct protein
Buffer:	20 mM HEPES, 500 mM NaCl, 0.5 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 Jun 29

R_g^Guinier	2.4	nm
D_max	9.6	nm
Volume^Porod	62	nm³