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10 hits found for Protein map

SASDJY3 – Immunoglobulin HUI-018 Fab in complex with human insulin

Insulin (Insulin B chain and Insulin A chain)HUI-018 Fab experimental SAS data
OTHER model
Sample: Insulin (Insulin B chain and Insulin A chain) monomer, 6 kDa Homo sapiens protein
HUI-018 Fab monomer, 47 kDa Mus musculus protein
Buffer: 20 mM HEPES, 140 mM NaCl, pH: 7.5
Experiment: SAXS data collected at I911-4, MAX IV on 2013 Mar 7
...Mapping and Binding Properties Protein Science (2020)
Johansson E, Wu X, Yu B, Yang Z, Cao Z, Wiberg C, Jeppesen C, Poulsen F
RgGuinier 3.4 nm
Dmax 10.7 nm
VolumePorod 86 nm3

SASDJZ3 – Immunoglobulin HUI-018 Fab in complex with human insulin at high concentration

Insulin (Insulin B chain and Insulin A chain)HUI-018 Fab experimental SAS data
OTHER model
Sample: Insulin (Insulin B chain and Insulin A chain) monomer, 6 kDa Homo sapiens protein
HUI-018 Fab monomer, 47 kDa Mus musculus protein
Buffer: 20 mM HEPES, 140 mM NaCl, pH: 7.5
Experiment: SAXS data collected at I911-4, MAX IV on 2013 Mar 7
...Mapping and Binding Properties Protein Science (2020)
Johansson E, Wu X, Yu B, Yang Z, Cao Z, Wiberg C, Jeppesen C, Poulsen F
RgGuinier 3.7 nm
Dmax 13.4 nm
VolumePorod 105 nm3

SASDJ24 – Immunoglobulin HUI-018 Fab and OXI-005 Fab in a ternary complex with porcine insulin

HUI-018 FabInsulin (Insulin B chain and Insulin A chain)OXI-005 Fab experimental SAS data
OTHER model
Sample: HUI-018 Fab monomer, 47 kDa Mus musculus protein
Insulin (Insulin B chain and Insulin A chain) monomer, 6 kDa Sus scrofa protein
OXI-005 Fab monomer, 47 kDa Mus musculus protein
Buffer: 20 mM HEPES, 140 mM NaCl, pH: 7.5
Experiment: SAXS data collected at Rigaku BioSAXS-2000, Novo Nordisk A/S on 2019 Mar 28
...Mapping and Binding Properties Protein Science (2020)
Johansson E, Wu X, Yu B, Yang Z, Cao Z, Wiberg C, Jeppesen C, Poulsen F
RgGuinier 4.5 nm
Dmax 14.2 nm
VolumePorod 138 nm3

SASDVL2 – ...MAP domain-containing protein

Cathepsin GMAP domain-containing proteinNeutrophil elastase experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Cathepsin G monomer, 25 kDa Homo sapiens protein
MAP domain-containing protein monomer, 13 kDa Staphylococcus aureus (strain … protein
Neutrophil elastase monomer, 23 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 140 mM NaCl, pH: 7.4
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2023 Jun 3
S. aureus Eap is a polyvalent inhibitor of neutrophil serine proteases. J Biol Chem 300(9):107627 (2024)
Mishra N, Gido CD, Herdendorf TJ, Hammel M, Hura GL, Fu ZQ, Geisbrecht BV
RgGuinier 2.8 nm
Dmax 9.4 nm
VolumePorod 77 nm3

SASDVM2 – ...Protein map Eap4-domain-4 (Δ347-476Δ) (Complex: NE/Eap4/NE)

Neutrophil elastaseProtein map experimental SAS data
PHENIX model
Sample: Neutrophil elastase tetramer, 93 kDa Homo sapiens protein
Protein map dimer, 24 kDa Staphylococcus aureus (strain … protein
Buffer: 20 mM HEPES, 140 mM NaCl, pH: 7.4
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2023 Jun 26
S. aureus Eap is a polyvalent inhibitor of neutrophil serine proteases. J Biol Chem 300(9):107627 (2024)
Mishra N, Gido CD, Herdendorf TJ, Hammel M, Hura GL, Fu ZQ, Geisbrecht BV
RgGuinier 3.7 nm
Dmax 11.0 nm
VolumePorod 163 nm3

SASDVF2 – ...protein (Eap) in unbound form

Protein map experimental SAS data
MULTIFOXS model
Sample: Protein map monomer, 50 kDa Staphylococcus aureus (strain … protein
Buffer: 20 mM HEPES, 140 mM NaCl, pH: 7.4
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2023 Jun 3
S. aureus Eap is a polyvalent inhibitor of neutrophil serine proteases. J Biol Chem 300(9):107627 (2024)
Mishra N, Gido CD, Herdendorf TJ, Hammel M, Hura GL, Fu ZQ, Geisbrecht BV
RgGuinier 4.0 nm
VolumePorod 64 nm3

SASDVG2 – ...protein (Eap) bound to human cathepsin-G

Protein mapCathepsin G experimental SAS data
MULTIFOXS model
Sample: Protein map monomer, 50 kDa Staphylococcus aureus (strain … protein
Cathepsin G tetramer, 101 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 140 mM NaCl, pH: 7.4
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2023 Jun 3
S. aureus Eap is a polyvalent inhibitor of neutrophil serine proteases. J Biol Chem 300(9):107627 (2024)
Mishra N, Gido CD, Herdendorf TJ, Hammel M, Hura GL, Fu ZQ, Geisbrecht BV
RgGuinier 5.0 nm
Dmax 20.2 nm
VolumePorod 166 nm3

SASDVH2 – ...protein (Eap) bound to human neutrophil elastase

Protein mapNeutrophil elastase experimental SAS data
MULTIFOXS model
Sample: Protein map monomer, 50 kDa Staphylococcus aureus (strain … protein
Neutrophil elastase tetramer, 93 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 140 mM NaCl, pH: 7.4
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2023 Dec 6
S. aureus Eap is a polyvalent inhibitor of neutrophil serine proteases. J Biol Chem 300(9):107627 (2024)
Mishra N, Gido CD, Herdendorf TJ, Hammel M, Hura GL, Fu ZQ, Geisbrecht BV
RgGuinier 4.1 nm
Dmax 10.6 nm
VolumePorod 152 nm3

SASDVN2 – ...Protein Map Eap3 and Eap4 domains (Δ266-476)

Protein map experimental SAS data
MULTIFOXS model
Sample: Protein map monomer, 24 kDa Staphylococcus aureus (strain … protein
Buffer: 20 mM HEPES, 140 mM NaCl, pH: 7.4
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2023 Nov 17
S. aureus Eap is a polyvalent inhibitor of neutrophil serine proteases. J Biol Chem 300(9):107627 (2024)
Mishra N, Gido CD, Herdendorf TJ, Hammel M, Hura GL, Fu ZQ, Geisbrecht BV
RgGuinier 2.5 nm
Dmax 8.5 nm
VolumePorod 28 nm3

SASDVP2 – ...Protein Map Eap3 and Eap4 domains

Cathepsin GNeutrophil elastaseEap34 experimental SAS data
BILBOMD model
Sample: Cathepsin G tetramer, 101 kDa Homo sapiens protein
Neutrophil elastase tetramer, 93 kDa Homo sapiens protein
Eap34 dimer, 48 kDa Staphylococcus aureus (strain … protein
Buffer: 20 mM HEPES, 140 mM NaCl, pH: 7.4
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2023 Jun 3
S. aureus Eap is a polyvalent inhibitor of neutrophil serine proteases. J Biol Chem 300(9):107627 (2024)
Mishra N, Gido CD, Herdendorf TJ, Hammel M, Hura GL, Fu ZQ, Geisbrecht BV
RgGuinier 5.4 nm
Dmax 19.4 nm
VolumePorod 500 nm3