Small Angle Scattering Biological Data Bank SASBDB


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10 hits found for Newman

SASDHX2 – Dehydrodolichyl diphosphate synthase complex subunit DHDDS

Dehydrodolichyl diphosphate synthase complex subunit DHDDS experimental SAS data

Sample:	Dehydrodolichyl diphosphate synthase complex subunit DHDDS dimer, 78 kDa Homo sapiens protein
Buffer:	Tris-HCl, 150 mM NaCl, 20 mM 2-mercaptoethanol and 0.02% Triton-X100, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2018 May 2

Structural Characterization of Full-Length Human Dehydrodolichyl Diphosphate Synthase Using an Integrative Computational and Experimental Approach. Biomolecules 9(11) (2019)
...Newman H, Haitin Y

R_g^Guinier	3.2	nm
D_max	13.0	nm
Volume^Porod	122	nm³

SASDMC4 – Plasmodium falciparum tyrosyl-tRNA synthetase

Tyrosine--tRNA ligase experimental SAS data

Sample:	Tyrosine--tRNA ligase dimer, 87 kDa Plasmodium falciparum (isolate … protein
Buffer:	20 mM Tris-HCl, 150 mM NaCl, 0.5 mM TCEP, 0.1% sodium azide, pH: 7.4
Experiment:	SAXS data collected at SAXS/WAXS, Australian Synchrotron on 2021 Jun 4

Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy Science 376(6597):1074-1079 (2022)
...Newman W, Niles J, Lee M, Baum J, Ottilie S, Winzeler E, Creek D, Williamson N, Parker M, Brand S, Langston S, Dick L, Griffin M, Gould A, Tilley L

R_g^Guinier	3.7	nm
D_max	12.1	nm
Volume^Porod	126	nm³

SASDMD4 – Plasmodium falciparum tyrosyl-tRNA synthetase, S234C mutant

Tyrosine--tRNA ligase (S234C) experimental SAS data

Sample:	Tyrosine--tRNA ligase (S234C) dimer, 87 kDa Plasmodium falciparum (isolate … protein
Buffer:	20 mM Tris-HCl, 150 mM NaCl, 0.5 mM TCEP, 0.1% sodium azide, pH: 7.4
Experiment:	SAXS data collected at SAXS/WAXS, Australian Synchrotron on 2021 Jun 4

R_g^Guinier	3.7	nm
D_max	12.0	nm
Volume^Porod	124	nm³

SASDME4 – Human tyrosyl tRNA synthetase

Tyrosine--tRNA ligase, cytoplasmic experimental SAS data

Sample:	Tyrosine--tRNA ligase, cytoplasmic dimer, 82 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl, 150 mM NaCl, 0.5 mM TCEP, 0.1% sodium azide, pH: 7.4
Experiment:	SAXS data collected at SAXS/WAXS, Australian Synchrotron on 2021 Jun 4

R_g^Guinier	3.6	nm
D_max	11.5	nm
Volume^Porod	118	nm³

SASDKD8 – LuxR family transcriptional regulator, SmcR

LuxR family transcriptional regulator experimental SAS data

Sample:	LuxR family transcriptional regulator , 52 kDa Vibrio vulnificus protein
Buffer:	200 mM NaCl, 25 mM Tris, pH: 7.5
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Aug 8

The DNA binding domain of the Vibrio vulnificus SmcR transcription factor is flexible and binds diverse DNA sequences. Nucleic Acids Res 49(10):5967-5984 (2021)
Newman JD, Russell MM, Fan L, Wang YX, Gonzalez-Gutierrez G, van Kessel JC

R_g^Guinier	3.1	nm
D_max	12.0	nm
Volume^Porod	67	nm³

SASDKE8 – LuxR family transcriptional regulator, SmcR N55I mutant

LuxR family transcriptional regulator, N55I experimental SAS data

Sample:	LuxR family transcriptional regulator, N55I , 52 kDa Vibrio vulnificus protein
Buffer:	200 mM NaCl, 25 mM Tris, 1 mM DTT, 0.5 mM EDTA, pH: 7.5
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Dec 11

R_g^Guinier	3.0	nm
D_max	10.1	nm
Volume^Porod	45	nm³

SASDCT2 – Bromodomain-containing protein 2 (BRD2) tandem bromodomains

Bromodomain-containing protein 2 experimental SAS data

Sample:	Bromodomain-containing protein 2 monomer, 43 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, 2% glycerol, 0.5 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2017 Jan 13

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Mol Cell (2018)
...Newman JA, Stucki M, Pelletier L, Bandeira N, Wilson MD, Filippakopoulos P, Gingras AC

R_g^Guinier	5.7	nm
D_max	21.0	nm
Volume^Porod	220	nm³

SASDCS2 – Bromodomain-containing protein 3 (BRD3) tandem bromodomains

Bromodomain-containing protein 3 experimental SAS data

Sample:	Bromodomain-containing protein 3 monomer, 44 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, 2% glycerol, 0.5 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2017 Jan 13

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Mol Cell (2018)
...Newman JA, Stucki M, Pelletier L, Bandeira N, Wilson MD, Filippakopoulos P, Gingras AC

R_g^Guinier	6.2	nm
D_max	21.5	nm
Volume^Porod	210	nm³

SASDCR2 – Bromodomain-containing protein 4 (BRD4) tandem bromodomains

Bromodomain-containing protein 4 experimental SAS data

Sample:	Bromodomain-containing protein 4 monomer, 47 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, 2% glycerol, 0.5 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2017 Jan 13

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Mol Cell (2018)
...Newman JA, Stucki M, Pelletier L, Bandeira N, Wilson MD, Filippakopoulos P, Gingras AC

R_g^Guinier	6.3	nm
D_max	22.0	nm
Volume^Porod	251	nm³

SASDCU2 – Bromodomain testis-specific protein (BRDT) tandem bromodomains

Bromodomain testis-specific protein experimental SAS data

Sample:	Bromodomain testis-specific protein monomer, 43 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, 2% glycerol, 0.5 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2017 Jan 13

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Mol Cell (2018)
...Newman JA, Stucki M, Pelletier L, Bandeira N, Wilson MD, Filippakopoulos P, Gingras AC

R_g^Guinier	5.1	nm
D_max	20.0	nm
Volume^Porod	200	nm³

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