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6 hits found for Splicing factor 1

SASDM43 – ...1-ZnF1 tandem domains of RNA-binding protein 5 (C191G mutant)

RNA-binding protein 5 (I107T, C191G) experimental SAS data
Sample: ...107T, C191G) monomer, 14 kDa Homo sapiens protein
Buffer: ...1 mM DTT, pH: 6.5
Experiment: SAXS data collected at BM29, ESRF on ...16 Sep 26
...splicing factor RBM5. Nat Commun 14(1):4233 (2023)
Soni K, Jagtap PKA, Martínez-Lumbreras S, Bonnal S, Geerlof A, Stehle R, Simon B, Valcárcel J, Sattler M
RgGuinier 1.7 nm
Dmax 5.6 nm
VolumePorod 28 nm3

SASDM53 – ...1-ZnF1-RRM2 triple domains of RNA-binding protein 5 (C191G mutant)

RNA Binding Motif protein 5 (I107T, C191G) experimental SAS data
RNA Binding Motif protein 5 (I107T, C191G) Kratky plot
Sample: ...107T, C191G) monomer, 26 kDa Homo sapiens protein
Buffer: ...1 mM DTT, pH: 6.5
Experiment: SAXS data collected at ...1000, ...1035, Technische Universität München on ...17 Feb 9
...splicing factor RBM5. Nat Commun 14(1):4233 (2023)
Soni K, Jagtap PKA, Martínez-Lumbreras S, Bonnal S, Geerlof A, Stehle R, Simon B, Valcárcel J, Sattler M
RgGuinier 2.3 nm
Dmax 7.8 nm
VolumePorod 36 nm3

SASDM63 – ...1-ZnF1-RRM2 triple domains of RNA-binding protein 5 (C191G mutant) in complex with GGCU_12 RNA

RNA Binding Motif protein 5 (I107T, C191G)Caspase-2 derived RNA GGCU_12 experimental SAS data
OTHER model
Sample: ...107T, C191G) monomer, 26 kDa Homo sapiens protein
...12 monomer, 4 kDa RNA
Buffer: ...100 mM NaCl, 1 mM DTT, pH: 6.5
Experiment: SAXS data collected at ...1000, ...1035, Technische Universität München on ...17 Mar 1
...splicing factor RBM5. Nat Commun 14(1):4233 (2023)
Soni K, Jagtap PKA, Martínez-Lumbreras S, Bonnal S, Geerlof A, Stehle R, Simon B, Valcárcel J, Sattler M
RgGuinier 2.2 nm
Dmax 7.5 nm
VolumePorod 42 nm3

SASDSL7 – ...factor 40 homolog A (PRPF40A) in complex with Splicing factor 1 (SF1) C-terminal proline repeat

Pre-mRNA-processing factor 40 homolog ASplicing factor 1 experimental SAS data
Pre-mRNA-processing factor 40 homolog A Splicing factor 1 Kratky plot
Sample: ...factor 40 homolog A monomer, 11 kDa Homo sapiens protein
Splicing factor 1 monomer, 2 kDa Homo sapiens protein
Buffer: ...100 mM NaCl, 0.5 mM DTT, pH: 6.5
Experiment: SAXS data collected at BM29, ESRF on ...19
Intramolecular autoinhibition regulates the selectivity of PRPF40A tandem WW domains for proline-rich motifs. Nat Commun 15(1):3888 (2024)
Martínez-Lumbreras S, Träger LK, Mulorz MM, Payr M, Dikaya V, Hipp C, König J, Sattler M
RgGuinier 1.9 nm
Dmax 6.9 nm
VolumePorod 19 nm3

SASDMW7 – ...splicing factor, proline- and glutamine-rich with Non-POU domain-containing octamer-binding protein (SFPQ276-565/NONO53-312)

Splicing factor, proline- and glutamine-rich (276-565)Non-POU domain-containing octamer-binding protein (53-312) experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Splicing factor, proline- and glutamine-rich (276-565) monomer, 34 kDa Homo sapiens protein
...12) monomer, 30 kDa Homo sapiens protein
Buffer: 20 mM Tris pH 7.5, 250 mM NaCl, pH: 7.5
Experiment: SAXS data collected at SAXS/WAXS, Australian Synchrotron on ...15 Apr 28
Structural plasticity of the coiled-coil interactions in human SFPQ. Nucleic Acids Res (2024)
Koning HJ, Lai JY, Marshall AC, Stroeher E, Monahan G, Pullakhandam A, Knott GJ, Ryan TM, Fox AH, Whitten A, Lee M, Bond CS
RgGuinier 3.0 nm
Dmax 12.7 nm
VolumePorod 102 nm3

SASDUJ4 – ...factor 40 homolog A (PRPF40A) in complex with Splicing factor 1 (SF1) in HEPES buffer

Pre-mRNA-processing factor 40 homolog ASplicing factor 1 experimental SAS data
Pre-mRNA-processing factor 40 homolog A Splicing factor 1 Kratky plot
Sample: ...factor 40 homolog A monomer, 11 kDa Homo sapiens protein
Splicing factor 1 monomer, 2 kDa Homo sapiens protein
Buffer: ...100 mM NaCl, 1 mM DTT, pH: 6.6
Experiment: SAXS data collected at ...1000, Technische Universität München on 2024 Mar 8
Intramolecular autoinhibition regulates the selectivity of PRPF40A tandem WW domains for proline-rich motifs. Nat Commun 15(1):3888 (2024)
Martínez-Lumbreras S, Träger LK, Mulorz MM, Payr M, Dikaya V, Hipp C, König J, Sattler M
RgGuinier 1.9 nm
Dmax 6.0 nm
VolumePorod 19 nm3