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28 hits found for Manso

SASDBA4 – Plakin domain fragment of Human plectin (central region spectrin repeats: SR3-SR4-SR5-SR6 and SH3)

Plakin domain fragment of Human plectin encompassing spectrin repeats SR3-SR4-SR5-SR6 and SH3 experimental SAS data
DAMMIF model
Sample: Plakin domain fragment of Human plectin encompassing spectrin repeats SR3-SR4-SR5-SR6 and SH3 monomer, 53 kDa Homo sapiens protein
Buffer: 20 mM Sodium Phosphate 150 mM NaCl 5% glycerol 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2013 Nov 26
The Structure of the Plakin Domain of Plectin Reveals an Extended Rod-like Shape. J Biol Chem 291(36):18643-62 (2016)
...Manso JA, Buey RM, Carballido AM, Carabias A, Sonnenberg A, de Pereda JM
RgGuinier 5.1 nm
Dmax 21.0 nm
VolumePorod 91 nm3

SASDBB4 – Plakin domain fragment of Human plectin (C-terminal region spectrin repeats: SR7-SR8-SR9)

Plakin domain fragment of Human plectin encompassing spectrin repeats SR7-SR8-SR9 experimental SAS data
DAMMIF model
Sample: Plakin domain fragment of Human plectin encompassing spectrin repeats SR7-SR8-SR9 monomer, 43 kDa Homo sapiens protein
Buffer: 20 mM Sodium Phosphate 150 mM NaCl 5% glycerol 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2013 Nov 26
The Structure of the Plakin Domain of Plectin Reveals an Extended Rod-like Shape. J Biol Chem 291(36):18643-62 (2016)
...Manso JA, Buey RM, Carballido AM, Carabias A, Sonnenberg A, de Pereda JM
RgGuinier 4.2 nm
Dmax 17.0 nm
VolumePorod 57 nm3

SASDBC4 – Plakin domain of Human plectin (spectrin repeats: SR3-SR9)

Plakin domain fragment of Human plectin encompassing spectrin repeats SR3-SR9 experimental SAS data
DAMMIF model
Sample: Plakin domain fragment of Human plectin encompassing spectrin repeats SR3-SR9 monomer, 96 kDa Homo sapiens protein
Buffer: 20 mM Sodium Phosphate 150 mM NaCl 5% glycerol 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2013 Aug 13
The Structure of the Plakin Domain of Plectin Reveals an Extended Rod-like Shape. J Biol Chem 291(36):18643-62 (2016)
...Manso JA, Buey RM, Carballido AM, Carabias A, Sonnenberg A, de Pereda JM
RgGuinier 8.5 nm
Dmax 35.0 nm
VolumePorod 135 nm3

SASDBD4 – Plakin domain fragment of Human desmoplakin (C-terminal region spectrin repeats: SR7-SR8-SR9)

Plakin domain fragment of Human Desmoplakin encompassing spectrin repeats SR7-SR8-SR9 experimental SAS data
DAMMIF model
Sample: Plakin domain fragment of Human Desmoplakin encompassing spectrin repeats SR7-SR8-SR9 monomer, 42 kDa Homo sapiens protein
Buffer: 20 mM Sodium Phosphate 150 mM NaCl 5% glycerol 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2015 Sep 25
The Structure of the Plakin Domain of Plectin Reveals an Extended Rod-like Shape. J Biol Chem 291(36):18643-62 (2016)
...Manso JA, Buey RM, Carballido AM, Carabias A, Sonnenberg A, de Pereda JM
RgGuinier 4.4 nm
Dmax 17.5 nm
VolumePorod 69 nm3

SASDBE4 – Plakin domain of Human desmoplakin

Plakin domain of Human Desmoplakin experimental SAS data
Plakin domain of Human desmoplakin Rg histogram
Sample: Plakin domain of Human Desmoplakin monomer, 99 kDa Homo sapiens protein
Buffer: 20 mM Sodium Phosphate 150 mM NaCl 5% glycerol 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2015 Sep 25
The Structure of the Plakin Domain of Plectin Reveals an Extended Rod-like Shape. J Biol Chem 291(36):18643-62 (2016)
...Manso JA, Buey RM, Carballido AM, Carabias A, Sonnenberg A, de Pereda JM
RgGuinier 7.5 nm
Dmax 35.0 nm
VolumePorod 136 nm3

SASDM55 – GTP-binding domain of Candida albicans Ras-like protein 1

GTP-binding domain of Ras-like protein 1 experimental SAS data
MODELLER model
Sample: GTP-binding domain of Ras-like protein 1 monomer, 19 kDa protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 5% glycerol, 3 mM DTT, 5 mM MgCl2, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2020 Jun 21
Pathogen-specific structural features of Candida albicans Ras1 activation complex: uncovering new antifungal drug targets. mBio :e0063823 (2023)
Manso JA, Carabias A, Sárkány Z, de Pereda JM, Pereira PJB, Macedo-Ribeiro S
RgGuinier 1.6 nm
Dmax 4.1 nm
VolumePorod 26 nm3

SASDM65 – Candida albicans Ras-like protein 1

Ras-like protein 1 experimental SAS data
Candida albicans Ras-like protein 1 Rg histogram
Sample: Ras-like protein 1 monomer, 33 kDa Candida albicans protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 5% glycerol, 3 mM DTT, 5 mM MgCl2, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2020 Jun 21
Pathogen-specific structural features of Candida albicans Ras1 activation complex: uncovering new antifungal drug targets. mBio :e0063823 (2023)
Manso JA, Carabias A, Sárkány Z, de Pereda JM, Pereira PJB, Macedo-Ribeiro S
RgGuinier 3.6 nm
Dmax 15.1 nm
VolumePorod 56 nm3

SASDM75 – Ras-like protein 1 guanine nucleotide exchange factor region of Candida albicans cell division control protein 25

Cell division control protein 25 experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Cell division control protein 25 monomer, 55 kDa Candida albicans (strain … protein
Buffer: 20 mM Na-phosphate, 150 mM NaCl, 5% glycerol, 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2020 Jun 21
Pathogen-specific structural features of Candida albicans Ras1 activation complex: uncovering new antifungal drug targets. mBio :e0063823 (2023)
Manso JA, Carabias A, Sárkány Z, de Pereda JM, Pereira PJB, Macedo-Ribeiro S
RgGuinier 3.2 nm
Dmax 11.8 nm
VolumePorod 81 nm3

SASDM85 – GTP-binding domain of Candida albicans Ras-like protein 1 in complex with the guanine nucleotide exchange factor region of cell division control protein 25

GTP-binding domain of Ras-like protein 1Cell division control protein 25 experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: GTP-binding domain of Ras-like protein 1 monomer, 19 kDa protein
Cell division control protein 25 monomer, 55 kDa Candida albicans (strain … protein
Buffer: 20 mM Na-phosphate, 150 mM NaCl, 1 mM EDTA, 5% glycerol, 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2020 Jun 21
Pathogen-specific structural features of Candida albicans Ras1 activation complex: uncovering new antifungal drug targets. mBio :e0063823 (2023)
Manso JA, Carabias A, Sárkány Z, de Pereda JM, Pereira PJB, Macedo-Ribeiro S
RgGuinier 3.2 nm
Dmax 11.8 nm
VolumePorod 99 nm3

SASDM95 – Candida albicans Ras-like protein 1 in complex with the guanine nucleotide exchange factor region of cell division control protein 25

Ras-like protein 1Cell division control protein 25 experimental SAS data
Candida albicans Ras-like protein 1 in complex with the guanine nucleotide exchange factor region of cell division control protein 25 Rg histogram
Sample: Ras-like protein 1 monomer, 33 kDa Candida albicans protein
Cell division control protein 25 monomer, 55 kDa Candida albicans (strain … protein
Buffer: 20 mM Na-phosphate, 150 mM NaCl, 1 mM EDTA, 5% glycerol, 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2020 Jun 21
Pathogen-specific structural features of Candida albicans Ras1 activation complex: uncovering new antifungal drug targets. mBio :e0063823 (2023)
Manso JA, Carabias A, Sárkány Z, de Pereda JM, Pereira PJB, Macedo-Ribeiro S
RgGuinier 4.0 nm
Dmax 17.7 nm
VolumePorod 149 nm3

SASDDJ6 – SAM-dependent O-Methyltransferase from Mycobacterium hassiacum

Methyltransferase domain protein experimental SAS data
MODELLER model
Sample: Methyltransferase domain protein dimer, 51 kDa Mycolicibacterium hassiacum protein
Buffer: 20 mM bis-tris propane, 50 mM NaCl, 2 mM DTT, 5% (v/v) glycerol, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2017 Jun 21
Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1-O-methyltransferase specific for 3-O-methylated mannosides. Proc Natl Acad Sci U S A 116(3):835-844 (2019)
...Manso JA, Maranha A, Miranda V, Sequeira A, Ventura MR, Macedo-Ribeiro S, Pereira PJB, Empadinhas N
RgGuinier 2.6 nm
Dmax 8.5 nm
VolumePorod 86 nm3

SASDEL6 – Glucosamine kinase from Streptacidiphilus jiangxiensis

Glucosamine kinase experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Glucosamine kinase monomer, 48 kDa Streptacidiphilus jiangxiensis protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 10 mM MgCl2, 5 mM DTT, pH: 8
Experiment: SAXS data collected at BM29, ESRF on 2016 Nov 24
Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase Activity. MBio 10(3) (2019)
Manso JA, Nunes-Costa D, Macedo-Ribeiro S, Empadinhas N, Pereira PJB
RgGuinier 2.6 nm
Dmax 8.0 nm
VolumePorod 72 nm3

SASDEM6 – Glucosamine kinase from Streptacidiphilus jiangxiensis in presence of 0.2 M D-glucosamine

Glucosamine kinase experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Glucosamine kinase monomer, 48 kDa Streptacidiphilus jiangxiensis protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 10 mM MgCl2, 5 mM DTT, 0.2 M D-glucosamine, pH: 8
Experiment: SAXS data collected at BM29, ESRF on 2017 Nov 20
Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase Activity. MBio 10(3) (2019)
Manso JA, Nunes-Costa D, Macedo-Ribeiro S, Empadinhas N, Pereira PJB
RgGuinier 2.6 nm
Dmax 8.0 nm
VolumePorod 78 nm3

SASDEN6 – Glucosamine kinase from Streptacidiphilus jiangxiensis in presence of 1 mM ATP

Glucosamine kinase experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Glucosamine kinase monomer, 48 kDa Streptacidiphilus jiangxiensis protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 10 mM MgCl2, 5 mM DTT, 1 mM ATP, pH: 8
Experiment: SAXS data collected at BM29, ESRF on 2016 Nov 24
Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase Activity. MBio 10(3) (2019)
Manso JA, Nunes-Costa D, Macedo-Ribeiro S, Empadinhas N, Pereira PJB
RgGuinier 2.5 nm
Dmax 7.8 nm
VolumePorod 73 nm3

SASDEP6 – Glucosamine kinase from Streptacidiphilus jiangxiensis in presence of 0.2 M D-glucosamine and 1 mM ATP

Glucosamine kinase experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Glucosamine kinase monomer, 48 kDa Streptacidiphilus jiangxiensis protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 10 mM MgCl2, 5 mM DTT, 0.2 M D-glucosamine, 1 mM ATP, pH: 8
Experiment: SAXS data collected at BM29, ESRF on 2017 Nov 20
Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase Activity. MBio 10(3) (2019)
Manso JA, Nunes-Costa D, Macedo-Ribeiro S, Empadinhas N, Pereira PJB
RgGuinier 2.5 nm
Dmax 7.7 nm
VolumePorod 76 nm3

SASDEQ6 – Glucosamine kinase from Streptacidiphilus jiangxiensis in presence of 50 mM D-glucose

Glucosamine kinase experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Glucosamine kinase monomer, 48 kDa Streptacidiphilus jiangxiensis protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 10 mM MgCl2, 5 mM DTT, 50 mM D-glucose, pH: 8
Experiment: SAXS data collected at BM29, ESRF on 2018 Apr 13
Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase Activity. MBio 10(3) (2019)
Manso JA, Nunes-Costa D, Macedo-Ribeiro S, Empadinhas N, Pereira PJB
RgGuinier 2.6 nm
Dmax 8.0 nm
VolumePorod 73 nm3

SASDER6 – Glucosamine kinase from Streptacidiphilus jiangxiensis in presence of 50 mM D-glucose and 1 mM ATP

Glucosamine kinase experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Glucosamine kinase monomer, 48 kDa Streptacidiphilus jiangxiensis protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 10 mM MgCl2, 5 mM DTT, 50 mM D-glucose, 1 mM ATP, pH: 8
Experiment: SAXS data collected at BM29, ESRF on 2016 Nov 24
Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase Activity. MBio 10(3) (2019)
Manso JA, Nunes-Costa D, Macedo-Ribeiro S, Empadinhas N, Pereira PJB
RgGuinier 2.5 nm
Dmax 7.7 nm
VolumePorod 73 nm3

SASDAT6 – Integrin beta4, fragment of the cytoplasmic region encompassing the third and fourth FnIII domains

Integrin beta-4 experimental SAS data
DAMMIF model
Sample: Integrin beta-4 monomer, 23 kDa Homo sapiens protein
Buffer: 20 mM Sodium Phosphate 150 mM NaCl 5% glycerol 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2013 Aug 6
Combination of X-ray crystallography, SAXS and DEER to obtain the structure of the FnIII-3,4 domains of integrin α6β4. Acta Crystallogr D Biol Crystallogr 71(Pt 4):969-85 (2015)
...Manso JA, Buey RM, Urien H, Sonnenberg A, Jeschke G, de Pereda JM
RgGuinier 2.2 nm
Dmax 7.0 nm
VolumePorod 32 nm3

SASDDE8 – Integrin beta4, fragment of the cytoplasmic region that includes the final part of the connecting segment and the third and fourth FnIII domains (FnIII-3,4)

Integrin beta-4 fragment with final part of the connecting segment and the third and fourth FnIII domains experimental SAS data
Integrin beta4, fragment of the cytoplasmic region that includes the final part of the connecting segment and the third and fourth FnIII domains (FnIII-3,4) Rg histogram
Sample: Integrin beta-4 fragment with final part of the connecting segment and the third and fourth FnIII domains monomer, 26 kDa Homo sapiens protein
Buffer: 20 mM Sodium Phosphate 150 mM NaCl 5% glycerol 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2013 Nov 26
Integrin α6β4 Recognition of a Linear Motif of Bullous Pemphigoid Antigen BP230 Controls Its Recruitment to Hemidesmosomes. Structure 27(6):952-964.e6 (2019)
Manso JA, Gómez-Hernández M, Carabias A, Alonso-García N, García-Rubio I, Kreft M, Sonnenberg A, de Pereda JM
RgGuinier 2.4 nm
Dmax 9.5 nm
VolumePorod 37 nm3

SASDDF8 – Integrin beta4, fragment of the cytoplasmic region that includes the final part of the connecting segment and the third and fourth FnIII domains (FnIII-3,4). Point mutant R1463E

Integrin beta-4 (1436-1666) R1463E experimental SAS data
Integrin beta4, fragment of the cytoplasmic region that includes the final part of the connecting segment and the third and fourth FnIII domains (FnIII-3,4). Point mutant R1463E Rg histogram
Sample: Integrin beta-4 (1436-1666) R1463E monomer, 26 kDa Homo sapiens protein
Buffer: 20 mM Sodium Phosphate 150 mM NaCl 5% glycerol 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2013 Nov 26
Integrin α6β4 Recognition of a Linear Motif of Bullous Pemphigoid Antigen BP230 Controls Its Recruitment to Hemidesmosomes. Structure 27(6):952-964.e6 (2019)
Manso JA, Gómez-Hernández M, Carabias A, Alonso-García N, García-Rubio I, Kreft M, Sonnenberg A, de Pereda JM
RgGuinier 2.3 nm
Dmax 9.5 nm
VolumePorod 35 nm3

SASDDG8 – Integrin beta4, fragment of the cytoplasmic region that includes the final part of the connecting segment and the third and fourth FnIII domains (FnIII-3,4). Point mutant R1463A

Integrin beta-4 (1436-1666) R1463A experimental SAS data
Integrin beta4, fragment of the cytoplasmic region that includes the final part of the connecting segment and the third and fourth FnIII domains (FnIII-3,4). Point mutant R1463A Rg histogram
Sample: Integrin beta-4 (1436-1666) R1463A monomer, 26 kDa Homo sapiens protein
Buffer: 20 mM Sodium Phosphate 150 mM NaCl 5% glycerol 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2013 Nov 26
Integrin α6β4 Recognition of a Linear Motif of Bullous Pemphigoid Antigen BP230 Controls Its Recruitment to Hemidesmosomes. Structure 27(6):952-964.e6 (2019)
Manso JA, Gómez-Hernández M, Carabias A, Alonso-García N, García-Rubio I, Kreft M, Sonnenberg A, de Pereda JM
RgGuinier 2.4 nm
Dmax 9.5 nm
VolumePorod 36 nm3

SASDDH8 – Integrin beta4, fragment of the cytoplasmic region that includes the final part of the connecting segment and the third and fourth FnIII domains (FnIII-3,4). Point mutant A1468R

Integrin beta-4 (1436-1666) A1468R experimental SAS data
Integrin beta4, fragment of the cytoplasmic region that includes the final part of the connecting segment and the third and fourth FnIII domains (FnIII-3,4). Point mutant A1468R Rg histogram
Sample: Integrin beta-4 (1436-1666) A1468R monomer, 26 kDa Homo sapiens protein
Buffer: 20 mM Sodium Phosphate 150 mM NaCl 5% glycerol 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2013 Nov 26
Integrin α6β4 Recognition of a Linear Motif of Bullous Pemphigoid Antigen BP230 Controls Its Recruitment to Hemidesmosomes. Structure 27(6):952-964.e6 (2019)
Manso JA, Gómez-Hernández M, Carabias A, Alonso-García N, García-Rubio I, Kreft M, Sonnenberg A, de Pereda JM
RgGuinier 2.8 nm
Dmax 10.9 nm
VolumePorod 35 nm3

SASDDJ8 – Integrin beta4, fragment of the cytoplasmic region that includes the final part of the connecting segment and the third and fourth FnIII domains (FnIII-3,4). Point mutant A1468D

Integrin beta-4 (1436-1666) A1468D experimental SAS data
Integrin beta4, fragment of the cytoplasmic region that includes the final part of the connecting segment and the third and fourth FnIII domains (FnIII-3,4). Point mutant A1468D Rg histogram
Sample: Integrin beta-4 (1436-1666) A1468D monomer, 26 kDa Homo sapiens protein
Buffer: 20 mM Sodium Phosphate 150 mM NaCl 5% glycerol 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2013 Nov 26
Integrin α6β4 Recognition of a Linear Motif of Bullous Pemphigoid Antigen BP230 Controls Its Recruitment to Hemidesmosomes. Structure 27(6):952-964.e6 (2019)
Manso JA, Gómez-Hernández M, Carabias A, Alonso-García N, García-Rubio I, Kreft M, Sonnenberg A, de Pereda JM
RgGuinier 2.7 nm
Dmax 11.0 nm
VolumePorod 34 nm3

SASDDK8 – Integrin beta4, fragment of the cytoplasmic region that includes the final part of the connecting segment and the third and fourth FnIII domains (FnIII-3,4). Point mutant R1475E

Integrin beta-4 (1436-1666) R1475E experimental SAS data
Integrin beta4, fragment of the cytoplasmic region that includes the final part of the connecting segment and the third and fourth FnIII domains (FnIII-3,4). Point mutant R1475E Rg histogram
Sample: Integrin beta-4 (1436-1666) R1475E monomer, 26 kDa Homo sapiens protein
Buffer: 20 mM Sodium Phosphate 150 mM NaCl 5% glycerol 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2013 Nov 26
Integrin α6β4 Recognition of a Linear Motif of Bullous Pemphigoid Antigen BP230 Controls Its Recruitment to Hemidesmosomes. Structure 27(6):952-964.e6 (2019)
Manso JA, Gómez-Hernández M, Carabias A, Alonso-García N, García-Rubio I, Kreft M, Sonnenberg A, de Pereda JM
RgGuinier 2.6 nm
Dmax 9.5 nm
VolumePorod 42 nm3

SASDDL8 – Integrin beta4, fragment of the cytoplasmic region that includes the final part of the connecting segment and the third and fourth FnIII domains (FnIII-3,4). Point mutant R1475A

Integrin beta-4 (1436-1666) R1475A experimental SAS data
Integrin beta4, fragment of the cytoplasmic region that includes the final part of the connecting segment and the third and fourth FnIII domains (FnIII-3,4). Point mutant R1475A Rg histogram
Sample: Integrin beta-4 (1436-1666) R1475A monomer, 26 kDa Homo sapiens protein
Buffer: 20 mM Sodium Phosphate 150 mM NaCl 5% glycerol 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2013 Nov 26
Integrin α6β4 Recognition of a Linear Motif of Bullous Pemphigoid Antigen BP230 Controls Its Recruitment to Hemidesmosomes. Structure 27(6):952-964.e6 (2019)
Manso JA, Gómez-Hernández M, Carabias A, Alonso-García N, García-Rubio I, Kreft M, Sonnenberg A, de Pereda JM
RgGuinier 2.4 nm
Dmax 9.5 nm
VolumePorod 35 nm3

SASDDM8 – Integrin beta4, fragment of the cytoplasmic region that includes the final part of the connecting segment and the third and fourth FnIII domains (FnIII-3,4). Point mutant R1542E

Integrin beta-4 (1436-1666) R1542E experimental SAS data
Integrin beta4, fragment of the cytoplasmic region that includes the final part of the connecting segment and the third and fourth FnIII domains (FnIII-3,4). Point mutant R1542E Rg histogram
Sample: Integrin beta-4 (1436-1666) R1542E monomer, 26 kDa Homo sapiens protein
Buffer: 20 mM Sodium Phosphate 150 mM NaCl 5% glycerol 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2013 Nov 26
Integrin α6β4 Recognition of a Linear Motif of Bullous Pemphigoid Antigen BP230 Controls Its Recruitment to Hemidesmosomes. Structure 27(6):952-964.e6 (2019)
Manso JA, Gómez-Hernández M, Carabias A, Alonso-García N, García-Rubio I, Kreft M, Sonnenberg A, de Pereda JM
RgGuinier 2.3 nm
Dmax 9.5 nm
VolumePorod 35 nm3

SASDDN8 – Integrin beta4, fragment of the cytoplasmic region that includes the final part of the connecting segment and the third and fourth FnIII domains (FnIII-3,4). Point mutant R1542A

Integrin beta-4 (1436-1666) R1542A experimental SAS data
Integrin beta4, fragment of the cytoplasmic region that includes the final part of the connecting segment and the third and fourth FnIII domains (FnIII-3,4). Point mutant R1542A Rg histogram
Sample: Integrin beta-4 (1436-1666) R1542A monomer, 26 kDa Homo sapiens protein
Buffer: 20 mM Sodium Phosphate 150 mM NaCl 5% glycerol 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2013 Nov 26
Integrin α6β4 Recognition of a Linear Motif of Bullous Pemphigoid Antigen BP230 Controls Its Recruitment to Hemidesmosomes. Structure 27(6):952-964.e6 (2019)
Manso JA, Gómez-Hernández M, Carabias A, Alonso-García N, García-Rubio I, Kreft M, Sonnenberg A, de Pereda JM
RgGuinier 2.3 nm
Dmax 8.5 nm
VolumePorod 34 nm3

SASDDP8 – Integrin beta4, fragment of the cytoplasmic region that includes the final part of the connecting segment and the third and fourth FnIII domains (FnIII-3,4). Point mutant T1663R

Integrin beta-4 (1436-1666) T1663R experimental SAS data
Integrin beta4, fragment of the cytoplasmic region that includes the final part of the connecting segment and the third and fourth FnIII domains (FnIII-3,4). Point mutant T1663R Rg histogram
Sample: Integrin beta-4 (1436-1666) T1663R monomer, 26 kDa Homo sapiens protein
Buffer: 20 mM Sodium Phosphate 150 mM NaCl 5% glycerol 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2013 Nov 26
Integrin α6β4 Recognition of a Linear Motif of Bullous Pemphigoid Antigen BP230 Controls Its Recruitment to Hemidesmosomes. Structure 27(6):952-964.e6 (2019)
Manso JA, Gómez-Hernández M, Carabias A, Alonso-García N, García-Rubio I, Kreft M, Sonnenberg A, de Pereda JM
RgGuinier 2.4 nm
Dmax 9.5 nm
VolumePorod 35 nm3