Small Angle Scattering Biological Data Bank SASBDB

Browse by MODEL: Ab initio only

SASDAZ5 – NetrinVIV

Sample:	Netrin-1 monomer, 49 kDa Homo sapiens protein
Buffer:	25 MES mM 200 mM NaCl 50 mM Tris 0.2 M ammonium sulfate (NH4)2(SO4) 1mM calcium chloride CaCl2, pH: 7
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2013 Aug 26

The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue. Neuron 83(4):839-849 (2014)
Finci LI, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, Schenk G, Mertens HDT, Svergun DI, Zhang Y, Wang JH, Meijers R

R_g^Guinier	3.9	nm
D_max	13.5	nm
Volume^Porod	100	nm³

SASDA26 – DCC56

Deleted in Colorectal Cancer (FN5 & FN6) experimental SAS data

Sample:	Deleted in Colorectal Cancer (FN5 & FN6) monomer, 26 kDa Homo sapiens protein
Buffer:	25 MES mM 200 mM NaCl 50 mM Tris 0.2 M ammonium sulfate (NH4)2(SO4) 1mM calcium chloride CaCl2, pH: 7
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2013 Aug 26

R_g^Guinier	3.2	nm
D_max	11.0	nm
Volume^Porod	38	nm³

SASDLH5 – Aggregation state of Ataxin-3 protein

Sample:	Ataxin-3 monomer, 41 kDa Homo sapiens protein
Buffer:	phosphate buffered saline (PBS), pH: 7.4
Experiment:	SAXS data collected at EMBL X33, DORIS III, DESY on 2009 Dec 3

Interactions of ataxin-3 with its molecular partners in the protein machinery that sorts protein aggregates to the aggresome. Int J Biochem Cell Biol 51:58-64 (2014)
Bonanomi M, Mazzucchelli S, D'Urzo A, Nardini M, Konarev PV, Invernizzi G, Svergun DI, Vanoni M, Regonesi ME, Tortora P

R_g^Guinier	6.9	nm
D_max	25.0	nm
Volume^Porod	425	nm³

SASDLJ5 – Aggregation state of tubulin protein

Tubulin alpha-1A chain experimental SAS data

Sample:	Tubulin alpha-1A chain monomer, 50 kDa Homo sapiens protein
Buffer:	phosphate buffered saline (PBS), pH: 7.4
Experiment:	SAXS data collected at EMBL X33, DORIS III, DESY on 2009 Dec 3

R_g^Guinier	7.0	nm
D_max	25.0	nm
Volume^Porod	340	nm³

SASDLK5 – Aggregation state of ataxin-3-tubulin complex

Ataxin-3Tubulin alpha-1A chain experimental SAS data

Sample:	Ataxin-3 monomer, 41 kDa Homo sapiens protein Tubulin alpha-1A chain monomer, 50 kDa Homo sapiens protein
Buffer:	phosphate buffered saline (PBS), pH: 7.4
Experiment:	SAXS data collected at EMBL X33, DORIS III, DESY on 2009 Dec 3

R_g^Guinier	8.4	nm
D_max	30.0	nm
Volume^Porod	900	nm³

SASDAX5 – Endophilin-CoA complex

Endophilin-A1 BAR domainarachidonyl-CoA experimental SAS data

Sample:	Endophilin-A1 BAR domain dimer, 58 kDa Mus musculus protein Arachidonyl-CoA, 60 kDa
Buffer:	50 mM TRIS-HCL 300 mM NaCl, pH: 8
Experiment:	SAXS data collected at EMBL X33, DORIS III, DESY on 2006 Nov 27

Endophilin-A1 BAR domain interaction with arachidonyl CoA. Front Mol Biosci 1:20 (2014)
Petoukhov MV, Weissenhorn W, Svergun DI

R_g^Guinier	5.9	nm
D_max	19.0	nm
Volume^Porod	480	nm³

SASDMU2 – Hydrolytically Degradable Polymer Micelles for Drug Delivery (structure of hydrophobic substituent - 5α-cholestan-3-one) without Dox

Hydrolytically Degradable Polymer Micelles for Drug Delivery (structure of hydrophobic substituent - 5α-cholestan-3-one) without Dox experimental SAS data

Sample:	Hydrolytically Degradable Polymer Micelles for Drug Delivery (structure of hydrophobic substituent - 5α-cholestan-3-one) without Dox monomer, 125 kDa
Buffer:	phosphate buffer saline (PBS) (pH 5.0), pH: 5
Experiment:	SAXS data collected at EMBL X33, DORIS III, DESY on 2012 Aug 19

Hydrolytically degradable polymer micelles for drug delivery: a SAXS/SANS kinetic study. Biomacromolecules 14(11):4061-70 (2013)
Filippov SK, Franklin JM, Konarev PV, Chytil P, Etrych T, Bogomolova A, Dyakonova M, Papadakis CM, Radulescu A, Ulbrich K, Stepanek P, Svergun DI

R_g^Guinier	6.1	nm
D_max	20.5	nm

SASDMV2 – Hydrolytically Degradable Polymer Micelles for Drug Delivery (structure of hydrophobic substituent - 5α-cholestan-3-one) with Dox

Hydrolytically Degradable Polymer Micelles for Drug Delivery (structure of hydrophobic substituent - 5α-cholestan-3-one) with Dox (10%) experimental SAS data

Sample:	Hydrolytically Degradable Polymer Micelles for Drug Delivery (structure of hydrophobic substituent - 5α-cholestan-3-one) with Dox (10%) monomer, 220 kDa
Buffer:	phosphate buffer saline (PBS) (pH 5.0), pH: 5
Experiment:	SAXS data collected at EMBL X33, DORIS III, DESY on 2012 Aug 19

R_g^Guinier	7.5	nm
D_max	25.5	nm

SASDMW2 – Hydrolytically Degradable Polymer Micelles for Drug Delivery (structure of hydrophobic substituent - Opb-Chol) without Dox

Hydrolytically Degradable Polymer Micelles for Drug Delivery (structure of hydrophobic substituent - Opb-Chol) without Dox experimental SAS data

Sample:	Hydrolytically Degradable Polymer Micelles for Drug Delivery (structure of hydrophobic substituent - Opb-Chol) without Dox monomer, 125 kDa
Buffer:	phosphate buffer saline (PBS) (pH 5.0), pH: 5
Experiment:	SAXS data collected at EMBL X33, DORIS III, DESY on 2012 Aug 19

R_g^Guinier	6.4	nm
D_max	22.5	nm

SASDMX2 – Hydrolytically Degradable Polymer Micelles for Drug Delivery (structure of hydrophobic substituent - Opb-Chol) with Dox (10%)

Hydrolytically Degradable Polymer Micelles for Drug Delivery (structure of hydrophobic substituent - Opb-Chol) with Dox (10%) experimental SAS data

Sample:	Hydrolytically Degradable Polymer Micelles for Drug Delivery (structure of hydrophobic substituent - Opb-Chol) with Dox (10%) monomer, 225 kDa
Buffer:	phosphate buffer saline (PBS) (pH 5.0), pH: 5
Experiment:	SAXS data collected at EMBL X33, DORIS III, DESY on 2012 Aug 19

R_g^Guinier	10.0	nm
D_max	21.9	nm

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