Small Angle Scattering Biological Data Bank SASBDB


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202 hits found for Wang

SASDR32 – Human derived autoantibody mAb2G7 at pH 8.0

Human derived autoantibody mAb2G7 heavy chain, mAb2G7 VHHuman derived autoantibody mAb2G7 light chain, mAb2G7 VL experimental SAS data

Human derived autoantibody mAb2G7 heavy chain, mAb2G7 VH Human derived autoantibody mAb2G7 light chain, mAb2G7 VL Kratky plot

Sample:	Human derived autoantibody mAb2G7 heavy chain, mAb2G7 VH dimer, 103 kDa protein Human derived autoantibody mAb2G7 light chain, mAb2G7 VL dimer, 51 kDa protein
Buffer:	phosphate buffered saline, pH: 8
Experiment:	SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2022 Dec 8

Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis. Nat Struct Mol Biol (2024)
Wang H, Xie C, Deng B, Ding J, Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S

R_g^Guinier	5.0	nm
D_max	16.0	nm
Volume^Porod	260	nm³

SASDR42 – Human derived autoantibody mAb5F6 at pH 8.0

Sample:	Human derived autoantibody mAb2G7 heavy chain, mAb2G7 VH dimer, 103 kDa protein Human derived autoantibody mAb2G7 light chain, mAb2G7 VL dimer, 51 kDa protein
Buffer:	phosphate buffered saline, pH: 8
Experiment:	SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2022 Dec 8

R_g^Guinier	5.0	nm
D_max	15.8	nm
Volume^Porod	252	nm³

SASDR52 – Human GluN1-GluN2A NMDA receptor at pH 8.0

Glutamate receptor ionotropic, NMDA 1Glutamate receptor ionotropic, NMDA 2A experimental SAS data

Glutamate receptor ionotropic, NMDA 1 Glutamate receptor ionotropic, NMDA 2A Kratky plot

Sample:	Glutamate receptor ionotropic, NMDA 1 dimer, 193 kDa Homo sapiens protein Glutamate receptor ionotropic, NMDA 2A dimer, 191 kDa Homo sapiens protein
Buffer:	150 mM NaCl, 0.1% digitonin, 5 µM Cholesteryl Hemisuccinate TRIS Salt, 0.1 mM CHAPSO, 50 µM EDTA,1 mM Gly/Glu, 20 mM HEPES, pH: 8
Experiment:	SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2022 Dec 8

R_g^Guinier	6.6	nm
D_max	20.4	nm
Volume^Porod	1180	nm³

SASDR62 – Human GluN1-GluN2A NMDA receptor in complex with human derived autoantibody mAb2G7 at pH 8.0

Glutamate receptor ionotropic, NMDA 1Glutamate receptor ionotropic, NMDA 2AHuman derived autoantibody mAb2G7 heavy chain, mAb2G7 VHHuman derived autoantibody mAb2G7 light chain, mAb2G7 VL experimental SAS data

Sample:	Glutamate receptor ionotropic, NMDA 1 dimer, 193 kDa Homo sapiens protein Glutamate receptor ionotropic, NMDA 2A dimer, 191 kDa Homo sapiens protein Human derived autoantibody mAb2G7 heavy chain, mAb2G7 VH dimer, 103 kDa protein Human derived autoantibody mAb2G7 light chain, mAb2G7 VL dimer, 51 kDa protein
Buffer:	150 mM NaCl, 0.1% digitonin, 5 µM Cholesteryl Hemisuccinate TRIS Salt, 0.1 mM CHAPSO, 50 µM EDTA,1 mM Gly/Glu, 20 mM HEPES, pH: 8
Experiment:	SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2022 Dec 8

R_g^Guinier	7.7	nm
D_max	25.4	nm
Volume^Porod	1260	nm³

SASDR72 – Human GluN1-GluN2A NMDA receptor in complex with human derived autoantibody mAb5F6 at pH 8.0

Glutamate receptor ionotropic, NMDA 1Glutamate receptor ionotropic, NMDA 2AHuman derived autoantibody mAb5F6 heavy chain, mAb5F6 VHHuman derived autoantibody mAb5F6 light chain, mAb5F6 VL experimental SAS data

Sample:	Glutamate receptor ionotropic, NMDA 1 dimer, 193 kDa Homo sapiens protein Glutamate receptor ionotropic, NMDA 2A dimer, 191 kDa Homo sapiens protein Human derived autoantibody mAb5F6 heavy chain, mAb5F6 VH dimer, 104 kDa Homo sapiens protein Human derived autoantibody mAb5F6 light chain, mAb5F6 VL dimer, 52 kDa protein
Buffer:	150 mM NaCl, 0.1% digitonin, 5 µM Cholesteryl Hemisuccinate TRIS Salt, 0.1 mM CHAPSO, 50 µM EDTA,1 mM Gly/Glu, 20 mM HEPES, pH: 8
Experiment:	SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2022 Dec 8

R_g^Guinier	9.9	nm
D_max	31.7	nm
Volume^Porod	2500	nm³

SASDK82 – Full-length nonstructural protein 2 (nsP2) of Chikungunya virus (CHIKV)

Sample:	NsP2 protein monomer, 90 kDa Chikungunya virus protein
Buffer:	20 mM Hepes pH 7.4, 150 mM NaCl, 1 mM DTT, 5% glycerol, pH: 7.4
Experiment:	SAXS data collected at 23A, Taiwan Photon Source, NSRRC on 2019 Aug 10

Inter-domain Flexibility of Chikungunya Virus nsP2 Helicase-Protease Differentially Influences Viral RNA Replication and Infectivity. J Virol (2020)
...Wang S, Tan YB, Shih O, Utt A, Goh WY, Lian BJ, Chen MW, Jeng US, Merits A, Luo D

R_g^Guinier	3.9	nm
D_max	12.0	nm
Volume^Porod	134	nm³

SASDEF2 – Mitochondrial import inner membrane translocase complex TIM9·10

Mitochondrial import inner membrane translocase subunit TIM9Mitochondrial import inner membrane translocase subunit TIM10 experimental SAS data

Sample:	Mitochondrial import inner membrane translocase subunit TIM9 trimer, 31 kDa Saccharomyces cerevisiae protein Mitochondrial import inner membrane translocase subunit TIM10 trimer, 31 kDa Saccharomyces cerevisiae protein
Buffer:	50mM Tris, 150mM NaCl, pH: 7.4
Experiment:	SAXS data collected at BM29, ESRF on 2015 Aug 27

Structural Basis of Membrane Protein Chaperoning through the Mitochondrial Intermembrane Space. Cell 175(5):1365-1379.e25 (2018)
...Wang Y, Schütze C, Jores T, Melchionda L, Schönfisch B, Kalbacher H, Bersch B, Rapaport D, Brennich M, Lindorff-Larsen K, Wiedemann N, Schanda P

R_g^Guinier	2.7	nm
D_max	10.0	nm
Volume^Porod	103	nm³

SASDEG2 – Mitochondrial import inner membrane translocase complex TIM9·10 in complex with a precursor (GDP/GTP carrier (Ggc1))

Mitochondrial import inner membrane translocase subunit TIM9Mitochondrial import inner membrane translocase subunit TIM10Mitochondrial GTP/GDP carrier protein 1 experimental SAS data

Sample:	Mitochondrial import inner membrane translocase subunit TIM9 hexamer, 61 kDa Saccharomyces cerevisiae protein Mitochondrial import inner membrane translocase subunit TIM10 hexamer, 61 kDa Saccharomyces cerevisiae protein Mitochondrial GTP/GDP carrier protein 1 monomer, 33 kDa Saccharomyces cerevisiae protein
Buffer:	50mM Tris, 150mM NaCl, imidiazole, pH: 7.4
Experiment:	SAXS data collected at BM29, ESRF on 2016 Feb 22

R_g^Guinier	4.5	nm
D_max	16.0	nm
Volume^Porod	272	nm³

SASDJM2 – Flagellotropic bacteriophage YSD1 protein, YSD1_22 - Major Tail Protein

Major tail protein experimental SAS data

Sample:	Major tail protein monomer, 40 kDa Salmonella virus Chi protein
Buffer:	20 mM Tris, 150 mM NaCl, 0.03 % NaN3, 5.0 % glycerol, pH: 7.8
Experiment:	SAXS data collected at SAXS/WAXS, Australian Synchrotron on 2017 Mar 8

The architecture and stabilisation of flagellotropic tailed bacteriophages. Nat Commun 11(1):3748 (2020)
...Wang J, Pickard D, Venugopal H, Dougan G, Lithgow T, Coulibaly F

R_g^Guinier	3.3	nm
D_max	10.2	nm
Volume^Porod	54	nm³

SASDMN2 – Mouse Kirrel2 ectodomain

Kin of IRRE-like protein 2 experimental SAS data

Sample:	Kin of IRRE-like protein 2 dimer, 106 kDa Mus musculus protein
Buffer:	10 mM HEPES pH 7.2, 150 mM NaCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Aug 3

Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors. Cell Rep 37(5):109940 (2021)
Wang J, Vaddadi N, Pak JS, Park Y, Quilez S, Roman CA, Dumontier E, Thornton JW, Cloutier JF, Özkan E

R_g^Guinier	8.9	nm
D_max	39.0	nm

SASDMP2 – Mouse Kirrel3 ectodomain

Kin of IRRE-like protein 3 experimental SAS data

Sample:	Kin of IRRE-like protein 3 dimer, 106 kDa Mus musculus protein
Buffer:	10 mM HEPES pH 7.2, 150 mM NaCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Aug 3

R_g^Guinier	9.3	nm
D_max	34.5	nm

SASDTP2 – Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) wild type

Ubiquitin carboxyl-terminal hydrolase isozyme L1 experimental SAS data

Ubiquitin carboxyl-terminal hydrolase isozyme L1 Kratky plot

Sample:	Ubiquitin carboxyl-terminal hydrolase isozyme L1 monomer, 26 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, 1 mM TCEP, 0.03% NaN3, pH: 7.5
Experiment:	SAXS data collected at 13A, Taiwan Photon Source, NSRRC on 2023 Sep 2

Altered protein dynamics and a more reactive catalytic cysteine in a neurodegeneration-associated UCHL1 mutant. J Mol Biol :168438 (2024)
...Wang YS, Flaherty DP, Danny Hsu ST, Das C

R_g^Guinier	1.9	nm
D_max	5.9	nm
Volume^Porod	26	nm³

SASDMQ2 – Mouse Kirrel3 ectodomain - Q128A mutant

Kin of IRRE-like protein 3 (Q128A) experimental SAS data

Mouse Kirrel3 ectodomain - Q128A mutant Rg histogram

Sample:	Kin of IRRE-like protein 3 (Q128A) monomer, 53 kDa Mus musculus protein
Buffer:	10 mM HEPES pH 7.2, 150 mM NaCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Aug 3

R_g^Guinier	5.4	nm
D_max	21.3	nm

SASDTQ2 – Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) R178Q mutant

Ubiquitin carboxyl-terminal hydrolase isozyme L1 (R178Q) experimental SAS data

Ubiquitin carboxyl-terminal hydrolase isozyme L1 (R178Q) Kratky plot

Sample:	Ubiquitin carboxyl-terminal hydrolase isozyme L1 (R178Q) monomer, 26 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, 1 mM TCEP, 0.03% NaN3, pH: 7.5
Experiment:	SAXS data collected at 13A, Taiwan Photon Source, NSRRC on 2023 Sep 2

Altered protein dynamics and a more reactive catalytic cysteine in a neurodegeneration-associated UCHL1 mutant. J Mol Biol :168438 (2024)
...Wang YS, Flaherty DP, Danny Hsu ST, Das C

R_g^Guinier	1.9	nm
D_max	5.8	nm
Volume^Porod	25	nm³

SASDKT2 – Wild type double Element for Nuclear Expression (dENE)

Sample:	Wild type dENE monomer, 23 kDa RNA
Buffer:	50 mM KCl, 1.0 mM MgCl2, 10 mM MOPS, 25 uM EDTA, pH: 7
Experiment:	SAXS data collected at 16-ID (LiX), National Synchrotron Light Source II (NSLS-II) on 2019 Jun 7

Structural analyses of an RNA stability element interacting with poly(A) Proceedings of the National Academy of Sciences 118(14):e2026656118 (2021)
...Wang J, DeGregorio S, Vaidya A, Su Z, Pabit S, Chiu W, Pollack L, Steitz J

R_g^Guinier	2.8	nm
D_max	10.8	nm
Volume^Porod	31	nm³

SASDKU2 – Wild type double Element for Nuclear Expression (dENE) + Poly(A)20

Wild type dENE + Poly(A)20 experimental SAS data

Sample:	Wild type dENE + Poly(A)20 monomer, 30 kDa RNA
Buffer:	50 mM KCl, 1.0 mM MgCl2, 10 mM MOPS, 25 uM EDTA, pH: 7
Experiment:	SAXS data collected at 16-ID (LiX), National Synchrotron Light Source II (NSLS-II) on 2019 Jun 7

R_g^Guinier	2.8	nm
D_max	10.7	nm

SASDKV2 – Wild type double Element for Nuclear Expression (dENE) + Poly(A)25

Wild type dENE + Poly(A)25 experimental SAS data

Sample:	Wild type dENE + Poly(A)25 monomer, 31 kDa RNA
Buffer:	50 mM KCl, 1.0 mM MgCl2, 10 mM MOPS, 25 uM EDTA, pH: 7
Experiment:	SAXS data collected at 16-ID (LiX), National Synchrotron Light Source II (NSLS-II) on 2019 Jun 7

R_g^Guinier	2.9	nm
D_max	10.4	nm

SASDKW2 – Wild type double Element for Nuclear Expression (dENE) + Poly(A)30

Wild type dENE + Poly(A)30 experimental SAS data

Sample:	Wild type dENE + Poly(A)30 monomer, 33 kDa RNA
Buffer:	50 mM KCl, 1.0 mM MgCl2, 10 mM MOPS, 25 uM EDTA, pH: 7
Experiment:	SAXS data collected at 16-ID (LiX), National Synchrotron Light Source II (NSLS-II) on 2019 Jun 7

R_g^Guinier	2.9	nm
D_max	10.6	nm

SASDKX2 – double Element for Nuclear Expression (dENE) Mutant A

Sample:	A dENE monomer, 27 kDa RNA
Buffer:	50 mM KCl, 1.0 mM MgCl2, 10 mM MOPS, 25 uM EDTA, pH: 7
Experiment:	SAXS data collected at 16-ID (LiX), National Synchrotron Light Source II (NSLS-II) on 2019 Jun 7

R_g^Guinier	3.2	nm
D_max	10.9	nm

SASDKY2 – double Element for Nuclear Expression (dENE) Mutant A + Poly(A)20

A dENE + Poly(A)20 experimental SAS data

Sample:	A dENE + Poly(A)20 monomer, 34 kDa RNA
Buffer:	50 mM KCl, 1.0 mM MgCl2, 10 mM MOPS, 25 uM EDTA, pH: 7
Experiment:	SAXS data collected at 16-ID (LiX), National Synchrotron Light Source II (NSLS-II) on 2019 Jun 7

R_g^Guinier	3.2	nm
D_max	11.5	nm

SASDK23 – double Element for Nuclear Expression (dENE) Mutant A + Poly(A)30

A dENE + Poly(A)30 experimental SAS data

Sample:	A dENE + Poly(A)30 monomer, 37 kDa RNA
Buffer:	50 mM KCl, 1.0 mM MgCl2, 10 mM MOPS, 25 uM EDTA, pH: 7
Experiment:	SAXS data collected at 16-ID (LiX), National Synchrotron Light Source II (NSLS-II) on 2019 Jun 7

R_g^Guinier	3.3	nm
D_max	13.3	nm

SASDK33 – double Element for Nuclear Expression (dENE) Mutant B

Sample:	B dENE monomer, 24 kDa RNA
Buffer:	50 mM KCl, 1.0 mM MgCl2, 10 mM MOPS, 25 uM EDTA, pH: 7
Experiment:	SAXS data collected at 16-ID (LiX), National Synchrotron Light Source II (NSLS-II) on 2019 Sep 20

R_g^Guinier	2.9	nm
D_max	10.8	nm

SASDK43 – double Element for Nuclear Expression (dENE) Mutant B + Poly(A)30

B dENE + Poly(A)30 experimental SAS data

Sample:	B dENE + Poly(A)30 monomer, 34 kDa RNA
Buffer:	50 mM KCl, 1.0 mM MgCl2, 10 mM MOPS, 25 uM EDTA, pH: 7
Experiment:	SAXS data collected at 16-ID (LiX), National Synchrotron Light Source II (NSLS-II) on 2019 Sep 20

R_g^Guinier	3.2	nm
D_max	11.8	nm

SASDV53 – Fc-fused PTPRA ECD in PBS buffer

Receptor-type tyrosine-protein phosphatase alpha experimental SAS data

Sample:	Receptor-type tyrosine-protein phosphatase alpha dimer, 150 kDa Homo sapiens protein
Buffer:	10 mM phosphate, 137 mM NaCl, 2.7 mM KCl, pH: 7.4
Experiment:	SAXS data collected at 13A, Taiwan Photon Source, NSRRC on 2021 Aug 19

High Density of N- and O-Glycosylation Shields and Defines the Structural Dynamics of the Intrinsically Disordered Ectodomain of Receptor-type Protein Tyrosine Phosphatase Alpha JACS Au (2023)
...Wang Y, Sridharan D, Kuo C, Chien C, Uchihashi T, Kato K, Angata T, Meng T, Hsu S, Khoo K

R_g^Guinier	8.3	nm
D_max	35.3	nm

SASDK63 – double Element for Nuclear Expression (dENE) Mutant C

Sample:	C dENE monomer, 29 kDa RNA
Buffer:	50 mM KCl, 1.0 mM MgCl2, 10 mM MOPS, 25 uM EDTA, pH: 7
Experiment:	SAXS data collected at 16-ID (LiX), National Synchrotron Light Source II (NSLS-II) on 2019 Sep 20

R_g^Guinier	3.4	nm
D_max	12.4	nm

SASDK73 – double Element for Nuclear Expression (dENE) Crystal Structure

Sample:	Xtal dENE monomer, 28 kDa RNA
Buffer:	50 mM KCl, 1.0 mM MgCl2, 10 mM MOPS, 25 uM EDTA, pH: 7
Experiment:	SAXS data collected at G1, Cornell High Energy Synchrotron Source (CHESS) on 2019 Dec 5

R_g^Guinier	3.1	nm
D_max	11.0	nm

SASDK83 – double Element for Nuclear Expression (dENE) Mutant C + Poly(A)30

C dENE + Poly(A)30 experimental SAS data

Sample:	C dENE + Poly(A)30 monomer, 39 kDa RNA
Buffer:	50 mM KCl, 1.0 mM MgCl2, 10 mM MOPS, 25 uM EDTA, pH: 7
Experiment:	SAXS data collected at 16-ID (LiX), National Synchrotron Light Source II (NSLS-II) on 2019 Sep 20

R_g^Guinier	3.6	nm
D_max	14.8	nm

SASDU93 – multimodular GH16_3 containing a CBM and a catalytic domain

Glycosyl hydrolase, family 16 experimental SAS data

Sample:	Glycosyl hydrolase, family 16 monomer, 58 kDa Christiangramia forsetii (strain … protein
Buffer:	10 mM MOPS, 100 mM NaCl, pH: 7.8
Experiment:	SAXS data collected at SWING, SOLEIL on 2022 Dec 1

Unveiling the role of novel carbohydrate-binding modules in laminarin interaction of multimodular proteins from marine Bacteroidota during phytoplankton blooms. Environ Microbiol 26(5):e16624 (2024)
...Wang F, Welsch N, Dürwald A, Martin LT, Larocque R, Jouanneau D, Eisenack T, Thomas F, Trautwein-Schult A, Teeling H, Becher D, Schweder T, Czjzek M

R_g^Guinier	3.8	nm
D_max	12.9	nm
Volume^Porod	76	nm³

SASDKA3 – double Element for Nuclear Expression (dENE) Crystal Structure + Poly(A)25

Xtal dENE + Poly(A)25 experimental SAS data

Sample:	Xtal dENE + Poly(A)25 monomer, 36 kDa RNA
Buffer:	50 mM KCl, 1.0 mM MgCl2, 10 mM MOPS, 25 uM EDTA, pH: 7
Experiment:	SAXS data collected at G1, Cornell High Energy Synchrotron Source (CHESS) on 2019 Dec 5

R_g^Guinier	3.3	nm
D_max	12.4	nm

SASDUA3 – Surface glycan binding protein (Cf-SGBP) from Christiangramia forsetii

PKD domain-containing protein experimental SAS data

Sample:	PKD domain-containing protein monomer, 96 kDa Christiangramia forsetii (strain … protein
Buffer:	10 mM MOPS, 100 mM NaCl, pH: 7.8
Experiment:	SAXS data collected at SWING, SOLEIL on 2022 Dec 1

R_g^Guinier	5.0	nm
D_max	17.8	nm
Volume^Porod	138	nm³

SASDKB3 – double Element for Nuclear Expression (dENE) Crystal Structure + Poly(A)30

Xtal dENE + Poly(A)30 experimental SAS data

Sample:	Xtal dENE + Poly(A)30 monomer, 38 kDa RNA
Buffer:	50 mM KCl, 1.0 mM MgCl2, 10 mM MOPS, 25 uM EDTA, pH: 7
Experiment:	SAXS data collected at G1, Cornell High Energy Synchrotron Source (CHESS) on 2019 Dec 5

R_g^Guinier	3.5	nm
D_max	13.2	nm

SASDKC3 – double Element for Nuclear Expression (dENE) Mutant A + Poly(A)25

A dENE + Poly(A)25 experimental SAS data

Sample:	A dENE + Poly(A)25 monomer, 36 kDa RNA
Buffer:	50 mM KCl, 1.0 mM MgCl2, 10 mM MOPS, 25 uM EDTA, pH: 7
Experiment:	SAXS data collected at 16-ID (LiX), National Synchrotron Light Source II (NSLS-II) on 2019 Jun 7

R_g^Guinier	3.3	nm
D_max	12.4	nm

SASDKD3 – double Element for Nuclear Expression (dENE) Mutant B + Hairpin - Poly(A)30

B dENE + Hairpin - Poly(A)30 experimental SAS data

B dENE + Hairpin - Poly(A)30 Kratky plot

Sample:	B dENE + Hairpin - Poly(A)30 monomer, 39 kDa RNA
Buffer:	50 mM KCl, 1.0 mM MgCl2, 10 mM MOPS, 25 uM EDTA, pH: 7
Experiment:	SAXS data collected at 16-ID (LiX), National Synchrotron Light Source II (NSLS-II) on 2019 Sep 20

R_g^Guinier	3.5	nm
D_max	14.0	nm

SASDKE3 – double Element for Nuclear Expression (dENE) Crystal Structure + Poly(A)20

Xtal dENE + Poly(A)20 experimental SAS data

Sample:	Xtal dENE + Poly(A)20 monomer, 34 kDa RNA
Buffer:	50 mM KCl, 1.0 mM MgCl2, 10 mM MOPS, 25 uM EDTA, pH: 7
Experiment:	SAXS data collected at G1, Cornell High Energy Synchrotron Source (CHESS) on 2019 Dec 5

R_g^Guinier	3.2	nm
D_max	11.8	nm

SASDGF3 – Xrn1 resistance RNA1 from Zika virus

Xrn1 resistance RNA2 from Zika virus experimental SAS data

Sample:	Xrn1 resistance RNA2 from Zika virus monomer, 22 kDa Zika virus RNA
Buffer:	20mM Tris-HCl, 100mM NaCl, 5mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2016 Dec 9

Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Rep 20(11):e47016 (2019)
...Wang Y, Qin CF, Fang X

R_g^Guinier	2.4	nm
D_max	8.5	nm
Volume^Porod	34	nm³

SASDGG3 – Xrn1 resistance RNA1 from Dengue virus 2

Xrn1 resistance RNA1 from Dengue virus 2 experimental SAS data

Sample:	Xrn1 resistance RNA1 from Dengue virus 2 monomer, 21 kDa Dengue virus 2 RNA
Buffer:	20mM Tris-HCl, 100mM NaCl, 5mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at 14-ID-B (BioCARS), Advanced Photon Source (APS), Argonne National Laboratory on 2016 Dec 9

Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Rep 20(11):e47016 (2019)
...Wang Y, Qin CF, Fang X

R_g^Guinier	2.2	nm
D_max	8.0	nm
Volume^Porod	31	nm³

SASDGH3 – Xrn1 resistance RNA1-2 from Zika virus

Xrn1 resistance RNA1-2 from Dengue virus 2 experimental SAS data

Sample:	Xrn1 resistance RNA1-2 from Dengue virus 2 monomer, 46 kDa Dengue virus 2 RNA
Buffer:	20mM Tris-HCl, 100mM NaCl, 5mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2017 Apr 2

Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Rep 20(11):e47016 (2019)
...Wang Y, Qin CF, Fang X

R_g^Guinier	3.9	nm
D_max	13.4	nm
Volume^Porod	67	nm³

SASDNH3 – HIV-1 reverse transcriptase L289K mutation at 1 mg/mL

Gag-Pol polyprotein (HIV-1 reverse transcriptase C38V/C280S, L289K truncated to 1 - 556) experimental SAS data

Gag-Pol polyprotein (HIV-1 reverse transcriptase C38V/C280S, L289K truncated to 1 - 556) Kratky plot

Sample:	Gag-Pol polyprotein (HIV-1 reverse transcriptase C38V/C280S, L289K truncated to 1 - 556) monomer, 65 kDa Human immunodeficiency virus … protein
Buffer:	50 mM Bis-Tris pH 6.8, 100 mM NaCl, 1% glycerol, 0.02% w/v NaN3, pH: 6.8
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Jun 20

Relative domain orientation of the L289K HIV ‐1 reverse transcriptase monomer Protein Science 31(5) (2022)
...Wang Y, Ishima R

R_g^Guinier	3.2	nm
D_max	10.7	nm
Volume^Porod	91	nm³

SASDGJ3 – Xrn1 resistance RNA1 from West Nile virus

Xrn1 resistance RNA-1 from West Nile virus experimental SAS data

Sample:	Xrn1 resistance RNA-1 from West Nile virus monomer, 25 kDa West Nile virus RNA
Buffer:	20mM Tris-HCl, 100mM NaCl, 5mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2016 Dec 9

Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Rep 20(11):e47016 (2019)
...Wang Y, Qin CF, Fang X

R_g^Guinier	2.4	nm
D_max	8.4	nm
Volume^Porod	34	nm³

SASDNJ3 – HIV-1 reverse transcriptase L289K mutation at 2 mg/mL

Sample:	Gag-Pol polyprotein (HIV-1 reverse transcriptase C38V/C280S, L289K truncated to 1 - 556) monomer, 65 kDa Human immunodeficiency virus … protein
Buffer:	50 mM Bis-Tris pH 6.8, 100 mM NaCl, 1% glycerol, 0.02% w/v NaN3, pH: 6.8
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Jun 20

Relative domain orientation of the L289K HIV ‐1 reverse transcriptase monomer Protein Science 31(5) (2022)
...Wang Y, Ishima R

R_g^Guinier	3.2	nm
D_max	10.8	nm
Volume^Porod	91	nm³

SASDGK3 – Xrn1 resistance RNA1 from Murray Valley Encephalitis

Xrn1 resistance RNA-1 from Murray Valley Encephalitis experimental SAS data

Sample:	Xrn1 resistance RNA-1 from Murray Valley Encephalitis monomer, 26 kDa Murray Valley Encephalitis RNA
Buffer:	20mM Tris-HCl, 100mM NaCl, 5mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2016 Dec 9

Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Rep 20(11):e47016 (2019)
...Wang Y, Qin CF, Fang X

R_g^Guinier	2.4	nm
D_max	8.8	nm
Volume^Porod	31	nm³

SASDNK3 – HIV-1 reverse transcriptase L289K mutation at 4.3 mg/mL

Sample:	Gag-Pol polyprotein (HIV-1 reverse transcriptase C38V/C280S, L289K truncated to 1 - 556) monomer, 65 kDa Human immunodeficiency virus … protein
Buffer:	50 mM Bis-Tris pH 6.8, 100 mM NaCl, 1% glycerol, 0.02% w/v NaN3, pH: 6.8
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Jun 20

Relative domain orientation of the L289K HIV ‐1 reverse transcriptase monomer Protein Science 31(5) (2022)
...Wang Y, Ishima R

R_g^Guinier	3.2	nm
D_max	10.7	nm
Volume^Porod	93	nm³

SASDGL3 – 3'SL from Dengue virus 2

3'SL from Dengue virus 2 experimental SAS data

Sample:	3'SL from Dengue virus 2 monomer, 31 kDa Dengue virus 2 RNA
Buffer:	20mM Tris-HCl, 100mM NaCl, 5mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2017 Feb 24

Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Rep 20(11):e47016 (2019)
...Wang Y, Qin CF, Fang X

R_g^Guinier	3.6	nm
D_max	14.1	nm
Volume^Porod	40	nm³

SASDNL3 – HIV-1 reverse transcriptase L289K mutation (extrapolated to zero concentration)

Sample:	Gag-Pol polyprotein (HIV-1 reverse transcriptase C38V/C280S, L289K truncated to 1 - 556) monomer, 65 kDa Human immunodeficiency virus … protein
Buffer:	50 mM Bis-Tris pH 6.8, 100 mM NaCl, 1% glycerol, 0.02% w/v NaN3, pH: 6.8
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2021 Jun 20

Relative domain orientation of the L289K HIV ‐1 reverse transcriptase monomer Protein Science 31(5) (2022)
...Wang Y, Ishima R

R_g^Guinier	3.2	nm
D_max	11.1	nm
Volume^Porod	90	nm³

SASDGM3 – Xrn1 resistance RNA1-2 from Dengue virus 2

Sample:	Xrn1 resistance RNA1-2 from Dengue virus 2 monomer, 46 kDa Dengue virus 2 RNA
Buffer:	20mM Tris-HCl, 100mM NaCl, 5mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2016 Dec 9

Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Rep 20(11):e47016 (2019)
...Wang Y, Qin CF, Fang X

R_g^Guinier	3.5	nm
D_max	12.5	nm
Volume^Porod	65	nm³

SASDGN3 – Xrn1 resistance RNA2 from Zika virus

Sample:	Xrn1 resistance RNA2 from Zika virus monomer, 22 kDa Zika virus RNA
Buffer:	20mM Tris-HCl, 100mM NaCl, 5mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2017 Sep 11

Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Rep 20(11):e47016 (2019)
...Wang Y, Qin CF, Fang X

R_g^Guinier	2.1	nm
D_max	7.2	nm
Volume^Porod	29	nm³

SASDGP3 – Xrn1 resistance RNA1-2 from West Nile virus

Xrn1 resistance RNA1-2 from West Nile virus experimental SAS data

Sample:	Xrn1 resistance RNA1-2 from West Nile virus monomer, 75 kDa West Nile virus RNA
Buffer:	20mM Tris-HCl, 100mM NaCl, 5mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2017 Apr 2

Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Rep 20(11):e47016 (2019)
...Wang Y, Qin CF, Fang X

R_g^Guinier	4.7	nm
D_max	17.4	nm
Volume^Porod	235	nm³

SASDGQ3 – SL3 from West Nile virus

SL3 from West Nile virus experimental SAS data

Sample:	SL3 from West Nile virus monomer, 23 kDa West Nile virus RNA
Buffer:	20mM Tris-HCl, 100mM NaCl, 5mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2017 Jun 27

Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Rep 20(11):e47016 (2019)
...Wang Y, Qin CF, Fang X

R_g^Guinier	2.8	nm
D_max	9.5	nm
Volume^Porod	29	nm³

SASDGR3 – Xrn1 resistance RNA2 from Dengue virus 2

Xrn1 resistance RNA2 from Dengue virus 2 experimental SAS data

Sample:	Xrn1 resistance RNA2 from Dengue virus 2 monomer, 21 kDa Dengue virus 2 RNA
Buffer:	20mM Tris-HCl, 100mM NaCl, 5mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2017 Mar 16

Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Rep 20(11):e47016 (2019)
...Wang Y, Qin CF, Fang X

R_g^Guinier	2.2	nm
D_max	7.6	nm
Volume^Porod	29	nm³

SASDGS3 – DB12 from Dengue virus 2

DB12 from Dengue virus 2 experimental SAS data

Sample:	DB12 from Dengue virus 2 monomer, 56 kDa Dengue virus 2 RNA
Buffer:	20mM Tris-HCl, 100mM NaCl, 5mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2017 Feb 24

Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Rep 20(11):e47016 (2019)
...Wang Y, Qin CF, Fang X

R_g^Guinier	4.7	nm
D_max	16.2	nm
Volume^Porod	96	nm³

SASDGT3 – Xrn1 resistance RNA2 from West Nile virus

Xrn1 resistance RNA2 from West Nile virus experimental SAS data

Sample:	Xrn1 resistance RNA2 from West Nile virus monomer, 23 kDa West Nile virus RNA
Buffer:	20mM Tris-HCl, 100mM NaCl, 5mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2017 Apr 7

Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Rep 20(11):e47016 (2019)
...Wang Y, Qin CF, Fang X

R_g^Guinier	2.2	nm
D_max	7.7	nm
Volume^Porod	30	nm³

SASDGU3 – Xrn1 resistance RNA2 from Murray Valley Encephalitis

Xrn1 resistance RNA2 from Murray Valley Encephalitis experimental SAS data

Sample:	Xrn1 resistance RNA2 from Murray Valley Encephalitis monomer, 22 kDa Murray Valley Encephalitis RNA
Buffer:	20mM Tris-HCl, 100mM NaCl, 5mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2016 Dec 14

Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Rep 20(11):e47016 (2019)
...Wang Y, Qin CF, Fang X

R_g^Guinier	2.2	nm
D_max	8.2	nm
Volume^Porod	28	nm³

SASDMU3 – Overall conformation and interdomain arrangement of Vibrio collagenase VhaC in solution.

Vibrio collagenase VhaC experimental SAS data

Sample:	Vibrio collagenase VhaC monomer, 90 kDa Vibrio harveyi protein
Buffer:	10 mM Tris-HCl, 100 mM NaCl, pH: 8
Experiment:	SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2021 Jan 1

Structure of Vibrio collagenase VhaC provides insight into the mechanism of bacterial collagenolysis. Nat Commun 13(1):566 (2022)
Wang Y, Wang P, Cao HY, Ding HT, Su HN, Liu SC, Liu G, Zhang X, Li CY, Peng M, Li F, Li S, Chen Y, Chen XL, Zhang YZ

R_g^Guinier	4.3	nm
D_max	17.6	nm
Volume^Porod	148	nm³

SASDGV3 – DB12 from Zika virus

DB12 from Zika virus experimental SAS data

Sample:	DB12 from Zika virus monomer, 47 kDa Zika virus RNA
Buffer:	20mM Tris-HCl, 100mM NaCl, 5mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2017 Apr 2

Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Rep 20(11):e47016 (2019)
...Wang Y, Qin CF, Fang X

R_g^Guinier	3.3	nm
D_max	11.2	nm
Volume^Porod	92	nm³

SASDGW3 – DB12 from West Nile virus

DB12 from West Nile virus experimental SAS data

Sample:	DB12 from West Nile virus monomer, 59 kDa West Nile virus RNA
Buffer:	20mM Tris-HCl, 100mM NaCl, 5mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2017 Jan 19

Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Rep 20(11):e47016 (2019)
...Wang Y, Qin CF, Fang X

R_g^Guinier	3.9	nm
D_max	13.4	nm
Volume^Porod	160	nm³

SASDVW3 – Lipoprotein NlpI dimer bound to two asymmetrical murein DD-endopeptidase mMepS dimers at pH 7.0

Lipoprotein NlpIMurein DD-endopeptidase MepS/Murein LD-carboxypeptidase experimental SAS data

Sample:	Lipoprotein NlpI dimer, 63 kDa Escherichia coli (strain … protein Murein DD-endopeptidase MepS/Murein LD-carboxypeptidase tetramer, 73 kDa Escherichia coli (strain … protein
Buffer:	0.2 M Na/K phosphate pH 7.0, 2 mM 2-mercaptoethanol, pH: 7
Experiment:	SAXS data collected at TPS13A, NSRRC on 2023 Sep 7

Structural basis for recruitment of peptidoglycan endopeptidase MepS by lipoprotein NlpI. Nat Commun 15(1):5461 (2024)
Wang S, Huang CH, Lin TS, Yeh YQ, Fan YS, Wang SW, Tseng HC, Huang SJ, Chang YY, Jeng US, Chang CI, Tzeng SR

R_g^Guinier	3.5	nm
D_max	11.5	nm
Volume^Porod	123	nm³

SASDGX3 – 3'SL from Zika virus

3'SL from Zika virus experimental SAS data

Sample:	3'SL from Zika virus monomer, 32 kDa Zika virus RNA
Buffer:	20mM Tris-HCl, 100mM NaCl, 5mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2016 Dec 9

Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Rep 20(11):e47016 (2019)
...Wang Y, Qin CF, Fang X

R_g^Guinier	3.9	nm
D_max	14.1	nm
Volume^Porod	52	nm³

SASDGY3 – 3'SL from West Nile virus

3'SL from West Nile virus experimental SAS data

Sample:	3'SL from West Nile virus monomer, 31 kDa West Nile virus RNA
Buffer:	20mM Tris-HCl, 100mM NaCl, 5mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2017 Apr 7

Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Rep 20(11):e47016 (2019)
...Wang Y, Qin CF, Fang X

R_g^Guinier	3.5	nm
D_max	13.2	nm
Volume^Porod	39	nm³

SASDGZ3 – Subgenomic flavivirus RNAs from Zika virus

Subgenomic flavivirus RNA from Zika virus experimental SAS data

Subgenomic flavivirus RNAs from Zika virus Rg histogram

Sample:	Subgenomic flavivirus RNA from Zika virus monomer, 133 kDa Zika virus RNA
Buffer:	20mM Tris-HCl, 100mM NaCl, 5mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2017 Mar 13

Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Rep 20(11):e47016 (2019)
...Wang Y, Qin CF, Fang X

R_g^Guinier	7.5	nm
D_max	29.6	nm
Volume^Porod	230	nm³

SASDG24 – Subgenomic flavivirus RNAs from Dengue virus 2

Subgenomic flavivirus RNAs from Dengue virus 2 experimental SAS data

Subgenomic flavivirus RNAs from Dengue virus 2 Rg histogram

Sample:	Subgenomic flavivirus RNAs from Dengue virus 2 monomer, 137 kDa Dengue virus 2 RNA
Buffer:	20mM Tris-HCl, 100mM NaCl, 5mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2016 Dec 16

Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Rep 20(11):e47016 (2019)
...Wang Y, Qin CF, Fang X

R_g^Guinier	7.9	nm
D_max	30.5	nm
Volume^Porod	236	nm³

SASDG34 – Subgenomic flavivirus RNAs from West nile virus

Subgenomic flavivirus RNAs from West nile virus experimental SAS data

Subgenomic flavivirus RNAs from West nile virus Rg histogram

Sample:	Subgenomic flavivirus RNAs from West nile virus monomer, 170 kDa West Nile virus RNA
Buffer:	20mM Tris-HCl, 100mM NaCl, 5mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2017 Mar 13

Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Rep 20(11):e47016 (2019)
...Wang Y, Qin CF, Fang X

R_g^Guinier	7.9	nm
D_max	31.8	nm
Volume^Porod	261	nm³

SASDKA4 – Complement factor P, properdin (FP) dimer

Sample:	Properdin (dimer) dimer, 110 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 7.5
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 Nov 14

Properdin oligomers adopt rigid extended conformations supporting function. Elife 10 (2021)
...Wang Y, Lindorff-Larsen K, Arleth L, Andersen GR

R_g^Guinier	8.1	nm
D_max	24.0	nm

SASDKB4 – Complement factor P, properdin (FP) trimer

Properdin (trimer) experimental SAS data

Sample:	Properdin (trimer) trimer, 165 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 7.5
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 Nov 14

Properdin oligomers adopt rigid extended conformations supporting function. Elife 10 (2021)
...Wang Y, Lindorff-Larsen K, Arleth L, Andersen GR

R_g^Guinier	10.2	nm
D_max	27.0	nm

SASDKC4 – Complement factor P, properdin (FP) tetramer

Properdin (tetramer) experimental SAS data

Sample:	Properdin (tetramer) tetramer, 220 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 7.5
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 Nov 14

Properdin oligomers adopt rigid extended conformations supporting function. Elife 10 (2021)
...Wang Y, Lindorff-Larsen K, Arleth L, Andersen GR

R_g^Guinier	13.1	nm
D_max	36.0	nm

SASDGD4 – Mixed lineage leukemia protein-1 complex, MLL1-WDR5-ASH2L-RBBP5(2-381)

Retinoblastoma-binding protein 5Histone-lysine N-methyltransferase 2AWD repeat-containing protein 5Set1/Ash2 histone methyltransferase complex subunit ASH2 experimental SAS data

Sample:	Retinoblastoma-binding protein 5 monomer, 42 kDa Homo sapiens protein Histone-lysine N-methyltransferase 2A monomer, 25 kDa Homo sapiens protein WD repeat-containing protein 5 monomer, 34 kDa Homo sapiens protein Set1/Ash2 histone methyltransferase complex subunit ASH2 monomer, 60 kDa Homo sapiens protein
Buffer:	300 mM NaCl, 25mM Tris-HCl, 4% glycerol, 1 mM TCEP, pH: 8
Experiment:	SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2019 Jun 22

The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex. Nucleic Acids Res (2019)
...Wang X, Peng C, Su C, Li N, Li Y, Xu Y, Chen Y

R_g^Guinier	5.7	nm
D_max	18.6	nm
Volume^Porod	360	nm³

SASDGE4 – Mixed lineage leukemia protein-1 complex, MLL1-WDR5-ASH2L-RBBP5(2-480)

Histone-lysine N-methyltransferase 2AWD repeat-containing protein 5Set1/Ash2 histone methyltransferase complex subunit ASH2Retinoblastoma-binding protein 5 experimental SAS data

Sample:	Histone-lysine N-methyltransferase 2A monomer, 25 kDa Homo sapiens protein WD repeat-containing protein 5 monomer, 34 kDa Homo sapiens protein Set1/Ash2 histone methyltransferase complex subunit ASH2 monomer, 60 kDa Homo sapiens protein Retinoblastoma-binding protein 5 monomer, 53 kDa Homo sapiens protein
Buffer:	300 mM NaCl, 25mM Tris-HCl, 4% glycerol, 1 mM TCEP, pH: 8
Experiment:	SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2019 Jun 22

The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex. Nucleic Acids Res (2019)
...Wang X, Peng C, Su C, Li N, Li Y, Xu Y, Chen Y

R_g^Guinier	5.0	nm
D_max	15.3	nm
Volume^Porod	256	nm³

SASDGF4 – Mixed lineage leukemia protein-1 complex, MLL1-WDR5-ASH2L-RBBP5(2-480)L399A/L400A/I457A/L459A

Sample:	Histone-lysine N-methyltransferase 2A monomer, 25 kDa Homo sapiens protein WD repeat-containing protein 5 monomer, 34 kDa Homo sapiens protein Set1/Ash2 histone methyltransferase complex subunit ASH2 monomer, 60 kDa Homo sapiens protein Retinoblastoma-binding protein 5 monomer, 53 kDa Homo sapiens protein
Buffer:	300 mM NaCl, 25mM Tris-HCl, 4% glycerol, 1 mM TCEP, pH: 8
Experiment:	SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2019 Jun 22

The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex. Nucleic Acids Res (2019)
...Wang X, Peng C, Su C, Li N, Li Y, Xu Y, Chen Y

R_g^Guinier	5.3	nm
D_max	17.2	nm
Volume^Porod	313	nm³

SASDGG4 – Mixed lineage leukemia protein-1 complex, MLL1-WDR5-ASH2L-RBBP5(2-538)

Sample:	Histone-lysine N-methyltransferase 2A monomer, 25 kDa Homo sapiens protein WD repeat-containing protein 5 monomer, 34 kDa Homo sapiens protein Set1/Ash2 histone methyltransferase complex subunit ASH2 monomer, 60 kDa Homo sapiens protein Retinoblastoma-binding protein 5 monomer, 59 kDa Homo sapiens protein
Buffer:	300 mM NaCl, 25mM Tris-HCl, 4% glycerol, 1 mM TCEP, pH: 8
Experiment:	SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2019 Jun 22

The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex. Nucleic Acids Res (2019)
...Wang X, Peng C, Su C, Li N, Li Y, Xu Y, Chen Y

R_g^Guinier	5.0	nm
D_max	15.5	nm
Volume^Porod	282	nm³

SASDMM4 – Hepatitis C virus 5BSL3.2 RNA subdomain

Sample:	5BSL3.2 monomer, 15 kDa Hepatitis C virus … RNA
Buffer:	10 mM Tris-HCl, 0.1 mM EDTA, pH: 7
Experiment:	SAXS data collected at Rigaku BioSAXS-1000, NIDDK, NIH on 2019 Jun 2

The low-resolution structural models of hepatitis C virus RNA subdomain 5BSL3.2 and its distal complex with domain 3'X point to conserved regulatory mechanisms within the Flaviviridae family. Nucleic Acids Res (2022)
...Wang YX, Gallego J

R_g^Guinier	2.5	nm
D_max	7.6	nm
Volume^Porod	29	nm³

SASDMN4 – Hepatitis C virus 5BSL3.2 RNA subdomain

Sample:	5BSL3.2 monomer, 15 kDa Hepatitis C virus … RNA
Buffer:	10 mM Tris-HCl, 6 mM MgCl2, pH: 7
Experiment:	SAXS data collected at Rigaku BioSAXS-1000, NIDDK, NIH on 2019 Jun 2

R_g^Guinier	2.1	nm
D_max	7.0	nm
Volume^Porod	22	nm³

SASDMP4 – Hepatitis C virus RNA Domain 3'X mutant

Sample:	Domain 3'X mutant monomer, 32 kDa Hepatitis C virus … RNA
Buffer:	10 mM Tris-HCl, 0.1 mM EDTA, pH: 7
Experiment:	SAXS data collected at Rigaku BioSAXS-1000, NIDDK, NIH on 2019 Jun 2

R_g^Guinier	4.1	nm
D_max	14.7	nm
Volume^Porod	70	nm³

SASDMQ4 – Hepatitis C virus RNA Domain 3'X mutant

Sample:	Domain 3'X mutant monomer, 32 kDa Hepatitis C virus … RNA
Buffer:	10 mM Tris-HCl, 6 mM MgCl2, pH: 7
Experiment:	SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Jun 2

R_g^Guinier	3.3	nm
D_max	14.2	nm
Volume^Porod	50	nm³

SASDMR4 – Hepatitis C virus RNA Domain 3'X mutant - Subdomain 5BSL3.2 complex

Domain 3'X mutant - 5BSL3.2 complex experimental SAS data

Sample:	Domain 3'X mutant - 5BSL3.2 complex monomer, 42 kDa Hepatitis C virus … RNA
Buffer:	10 mM Tris-HCl, 6 mM MgCl2, pH: 7
Experiment:	SAXS data collected at Rigaku BioSAXS-1000, NIDDK, NIH on 2019 Jun 2

R_g^Guinier	4.2	nm
D_max	17.0	nm
Volume^Porod	88	nm³

SASDG35 – Mothers against decapentaplegic homolog 2, S2MH1E3

Mothers against decapentaplegic homolog 2 experimental SAS data

Mothers against decapentaplegic homolog 2 Kratky plot

Sample:	Mothers against decapentaplegic homolog 2 monomer, 19 kDa Homo sapiens protein
Buffer:	20 mM Tris, 150 mM NaCl, pH: 7.2
Experiment:	SAXS data collected at BM29, ESRF on 2015 Jul 2

Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling. Genes Dev 33(21-22):1506-1524 (2019)
...Wang Q, Zou Y, Morgani SM, Ruiz L, Kaczmarska Z, Su J, Torner C, Tian L, Hu J, Shu W, Agrawal S, Gomes T, Márquez JA, Hadjantonakis AK, Macias MJ, Massagué J

R_g^Guinier	1.9	nm
D_max	7.4	nm
Volume^Porod	35	nm³

SASDT35 – N-cadherin extracellular domains EC1-EC5

Sample:	Cadherin-2 dimer, 123 kDa Mus musculus protein
Buffer:	10 mM HEPES, 150 mM NaCl, 3 mM CaCl2, 0.02% NaN3, pH: 8
Experiment:	SAXS data collected at 13A, Taiwan Photon Source, NSRRC on 2023 May 1

Rapid simulation of glycoprotein structures by grafting and steric exclusion of glycan conformer libraries. Cell 187(5):1296-1311.e26 (2024)
...Wang YS, Hsu MF, Khoo KH, Hummer G, Hsu SD, Hanus C, Sikora M

R_g^Guinier	8.8	nm
D_max	40.0	nm
Volume^Porod	496	nm³

SASDC45 – Alpha domain of autotransporter protein UpaB from UPEC

Alpha domain of autotransporter protein UpaB experimental SAS data

Sample:	Alpha domain of autotransporter protein UpaB monomer, 48 kDa E. Coli CFT073 protein
Buffer:	25 mM HEPES, 150 mM NaCl, pH: 7
Experiment:	SAXS data collected at SAXS/WAXS, Australian Synchrotron on 2015 May 1

Unique structural features of a bacterial autotransporter adhesin suggest mechanisms for interaction with host macromolecules. Nat Commun 10(1):1967 (2019)
...Wang G, Luan CH, Moriel DG, Tan L, Peters KM, Phan MD, Gee CL, Ulett GC, Schembri MA, Heras B

R_g^Guinier	2.9	nm
D_max	10.5	nm
Volume^Porod	66	nm³

SASDG45 – Mothers against decapentaplegic homolog 2, S2MH1noE3

Sample:	Mothers against decapentaplegic homolog 2 monomer, 16 kDa Homo sapiens protein
Buffer:	20 mM Tris, 150 mM NaCl, pH: 7.2
Experiment:	SAXS data collected at BM29, ESRF on 2015 Jul 2

R_g^Guinier	1.7	nm
D_max	6.6	nm
Volume^Porod	31	nm³

SASDT45 – N-cadherin extracellular domains EC4-EC5

Sample:	Cadherin-2 monomer, 24 kDa Mus musculus protein
Buffer:	10 mM HEPES, 150 mM NaCl, 3 mM CaCl2, 0.02% NaN3, pH: 8
Experiment:	SAXS data collected at 13A, Taiwan Photon Source, NSRRC on 2023 May 1

R_g^Guinier	3.4	nm
D_max	12.6	nm
Volume^Porod	63	nm³

SASDQE5 – Nucleoside triphosphate pyrophosphohydrolase (1–185)

Nucleoside triphosphate pyrophosphohydrolase experimental SAS data

Sample:	Nucleoside triphosphate pyrophosphohydrolase dimer, 41 kDa Mycobacterium tuberculosis (strain … protein
Buffer:	20 mM Tris-HCl, 100 mM NaCl, pH: 7.5
Experiment:	SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2020 Dec 11

Structural analysis of the housecleaning nucleoside triphosphate pyrophosphohydrolase MazG from Mycobacterium tuberculosis Frontiers in Microbiology 14 (2023)
Wang S, Gao B, Chen A, Zhang Z, Wang S, Lv L, Zhao G, Li J

R_g^Guinier	2.7	nm
D_max	8.4	nm
Volume^Porod	64	nm³

SASDSJ5 – 15mer poly-ADP ribose (PAR15) in 100mM NaCl

15mer of adenosine diphosphate ribose (poly-ADP ribose) experimental SAS data

Sample:	15mer of adenosine diphosphate ribose (poly-ADP ribose) monomer, 8 kDa synthetic construct
Buffer:	100 mM NaCl, 20 mM Tris-HCl, pH: 7.4
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Apr 21

Cation-induced intramolecular coil-to-globule transition in poly(ADP-ribose). Nat Commun 15(1):7901 (2024)
Wang T, Coshic K, Badiee M, McDonald MR, Aksimentiev A, Pollack L, Leung AKL

R_g^Guinier	2.4	nm
D_max	10.0	nm
Volume^Porod	15	nm³

SASDSK5 – 15mer poly-ADP ribose (PAR15) in 100mM NaCl + 1mM MgCl2

Sample:	15mer of adenosine diphosphate ribose (poly-ADP ribose) monomer, 8 kDa synthetic construct
Buffer:	20 mM Tris-HCl, 1 mM MgCl2, 100 mM NaCl, pH: 7.4
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Apr 21

Cation-induced intramolecular coil-to-globule transition in poly(ADP-ribose). Nat Commun 15(1):7901 (2024)
Wang T, Coshic K, Badiee M, McDonald MR, Aksimentiev A, Pollack L, Leung AKL

R_g^Guinier	2.3	nm
D_max	9.0	nm
Volume^Porod	14	nm³

SASDSL5 – 22mer poly-ADP ribose (PAR22) in 100mM NaCl

22mer of adenosine diphosphate ribose (poly-ADP ribose) experimental SAS data

Sample:	22mer of adenosine diphosphate ribose (poly-ADP ribose) monomer, 12 kDa synthetic construct
Buffer:	100 mM NaCl, 20 mM Tris-HCl, pH: 7.4
Experiment:	SAXS data collected at 16-ID (LiX), National Synchrotron Light Source II (NSLS-II) on 2022 Apr 21

Cation-induced intramolecular coil-to-globule transition in poly(ADP-ribose). Nat Commun 15(1):7901 (2024)
Wang T, Coshic K, Badiee M, McDonald MR, Aksimentiev A, Pollack L, Leung AKL

R_g^Guinier	3.3	nm
D_max	14.0	nm
Volume^Porod	32	nm³

SASDSM5 – 22mer poly-ADP ribose (PAR22) in 100mM NaCl + 1mM MgCl2

Sample:	22mer of adenosine diphosphate ribose (poly-ADP ribose) monomer, 12 kDa synthetic construct
Buffer:	20 mM Tris-HCl, 1 mM MgCl2, 100 mM NaCl, pH: 7.4
Experiment:	SAXS data collected at 16-ID (LiX), National Synchrotron Light Source II (NSLS-II) on 2022 Apr 21

Cation-induced intramolecular coil-to-globule transition in poly(ADP-ribose). Nat Commun 15(1):7901 (2024)
Wang T, Coshic K, Badiee M, McDonald MR, Aksimentiev A, Pollack L, Leung AKL

R_g^Guinier	2.6	nm
D_max	10.5	nm
Volume^Porod	21	nm³

SASDSN5 – A and C rich mixed sequence single stranded RNA in 100mM NaCl

Mixed sequence single stranded RNA, rich in A and C bases experimental SAS data

Mixed sequence single stranded RNA, rich in A and C bases Kratky plot

Sample:	Mixed sequence single stranded RNA, rich in A and C bases monomer, 10 kDa synthetic construct RNA
Buffer:	100 mM NaCl, 10 mM MOPS, 20 µM EDTA, pH: 7
Experiment:	SAXS data collected at Xenocs BioXolver L with GeniX3D, University of Copenhagen, Department of Drug Design and Pharmacology on 2022 Aug 19

Mixed sequence single stranded RNA in 100mM NaCl
Tong Wang

R_g^Guinier	2.2	nm
D_max	7.6	nm
Volume^Porod	15	nm³

SASDAZ5 – NetrinVIV

Sample:	Netrin-1 monomer, 49 kDa Homo sapiens protein
Buffer:	25 MES mM 200 mM NaCl 50 mM Tris 0.2 M ammonium sulfate (NH4)2(SO4) 1mM calcium chloride CaCl2, pH: 7
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2013 Aug 26

The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue. Neuron 83(4):839-849 (2014)
...Wang JH, Meijers R

R_g^Guinier	3.9	nm
D_max	13.5	nm
Volume^Porod	100	nm³

SASDBZ5 – Enzyme I-Ntr (residues 170-424) in complex with NPr (residues 1-85)

Phosphocarrier protein NPrPhosphoenolpyruvate-protein phosphotransferase PtsP experimental SAS data

Sample:	Phosphocarrier protein NPr monomer, 9 kDa Escherichia coli protein Phosphoenolpyruvate-protein phosphotransferase PtsP monomer, 28 kDa Escherichia coli protein
Buffer:	10 mM Tris 150 mM NaCl 0.5 mM EDTA, pH: 7.5
Experiment:	SAXS data collected at Rigaku BioSAXS-1000, NIDDK, NIH on 2015 Jan 30

Structure of the NPr:EINNtr Complex: Mechanism for Specificity in Paralogous Phosphotransferase Systems. Structure 24(12):2127-2137 (2016)
...Wang G, Botos I, Schwieters CD, Buchanan SK, Peterkofsky A, Tjandra N

R_g^Guinier	2.3	nm
D_max	8.2	nm
Volume^Porod	52	nm³

SASDA26 – DCC56

Deleted in Colorectal Cancer (FN5 & FN6) experimental SAS data

Sample:	Deleted in Colorectal Cancer (FN5 & FN6) monomer, 26 kDa Homo sapiens protein
Buffer:	25 MES mM 200 mM NaCl 50 mM Tris 0.2 M ammonium sulfate (NH4)2(SO4) 1mM calcium chloride CaCl2, pH: 7
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2013 Aug 26

The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue. Neuron 83(4):839-849 (2014)
...Wang JH, Meijers R

R_g^Guinier	3.2	nm
D_max	11.0	nm
Volume^Porod	38	nm³

SASDP56 – SARS-CoV-2 non-structural protein 8 (nsp8, dimer) in 250 mM NaCl buffer

Replicase polyprotein 1a (Non-structural protein 8, SARS-CoV-2) experimental SAS data

Replicase polyprotein 1a (Non-structural protein 8, SARS-CoV-2) Kratky plot

Sample:	Replicase polyprotein 1a (Non-structural protein 8, SARS-CoV-2) dimer, 44 kDa Severe acute respiratory … protein
Buffer:	20 mM HEPES pH 7.4, 250 mM NaCl, pH: 7.4
Experiment:	SANS data collected at BL01-Small Angle Neutron Scattering, China Spallation Neutron Source on 2021 Jul 19

Multiscale characterization reveals oligomerization dependent phase separation of primer-independent RNA polymerase nsp8 from SARS-CoV-2. Commun Biol 5(1):925 (2022)
...Wang H, Liu J

R_g^Guinier

4.1

SASDP66 – SARS-CoV-2 non-structural protein 8 (nsp8, dimer) in 500 mM NaCl buffer

Sample:	Replicase polyprotein 1a (Non-structural protein 8, SARS-CoV-2) dimer, 44 kDa Severe acute respiratory … protein
Buffer:	20 mM HEPES pH 7.4, 500 mM NaCl, pH: 7.4
Experiment:	SANS data collected at BL01-Small Angle Neutron Scattering, China Spallation Neutron Source on 2021 Jul 19

Multiscale characterization reveals oligomerization dependent phase separation of primer-independent RNA polymerase nsp8 from SARS-CoV-2. Commun Biol 5(1):925 (2022)
...Wang H, Liu J

R_g^Guinier	3.8	nm
D_max	14.0	nm
Volume^Porod	98	nm³

SASDA76 – NetrinVIV DCC56 complex

Netrin-1Deleted in Colorectal Cancer (FN5 & FN6) experimental SAS data

Netrin-1 Deleted in Colorectal Cancer (FN5 & FN6) Kratky plot

Sample:	Netrin-1 monomer, 49 kDa Homo sapiens protein Deleted in Colorectal Cancer (FN5 & FN6) monomer, 26 kDa Homo sapiens protein
Buffer:	25 MES mM 200 mM NaCl 50 mM Tris 0.2 M ammonium sulfate (NH4)2(SO4) 1mM calcium chloride CaCl2, pH: 7
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2013 Oct 31

The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue. Neuron 83(4):839-849 (2014)
...Wang JH, Meijers R

R_g^Guinier	5.1	nm
D_max	17.0	nm
Volume^Porod	120	nm³

SASDP76 – SARS-CoV-2 non-structural protein 8 (nsp8, dimer) in 1000 mM NaCl buffer

Sample:	Replicase polyprotein 1a (Non-structural protein 8, SARS-CoV-2) dimer, 44 kDa Severe acute respiratory … protein
Buffer:	20 mM HEPES pH 7.4, 1000 mM NaCl, pH: 7.4
Experiment:	SANS data collected at BL01-Small Angle Neutron Scattering, China Spallation Neutron Source on 2021 Jul 19

Multiscale characterization reveals oligomerization dependent phase separation of primer-independent RNA polymerase nsp8 from SARS-CoV-2. Commun Biol 5(1):925 (2022)
...Wang H, Liu J

R_g^Guinier	3.8	nm
D_max	14.0	nm
Volume^Porod	100	nm³

SASDA86 – NetrinVIV DCC56(M933R) complex

Netrin-1Deleted in Colorectal Cancer (FN5 & FN6) M933R mutant experimental SAS data

Netrin-1 Deleted in Colorectal Cancer (FN5 & FN6) M933R mutant Kratky plot

Sample:	Netrin-1 monomer, 49 kDa Homo sapiens protein Deleted in Colorectal Cancer (FN5 & FN6) M933R mutant monomer, 26 kDa Homo sapiens protein
Buffer:	25 MES mM 200 mM NaCl 50 mM Tris 0.2 M ammonium sulfate (NH4)2(SO4) 1mM calcium chloride CaCl2, pH: 7
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2013 Aug 26

The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue. Neuron 83(4):839-849 (2014)
...Wang JH, Meijers R

R_g^Guinier	4.0	nm
D_max	14.0	nm
Volume^Porod	95	nm³

SASDB86 – apo-BRD4

Bromodomain-containing protein 4 experimental SAS data

Sample:	Bromodomain-containing protein 4 monomer, 56 kDa Homo sapiens protein
Buffer:	20mM Hepes, 100mM NaCl, 1mM Tris(2-carboxyethyl)phosphine hydrochloride, pH: 7.4
Experiment:	SAXS data collected at BM29, ESRF on 2014 Sep 12

Potent and selective bivalent inhibitors of BET bromodomains. Nat Chem Biol 12(12):1097-1104 (2016)
...Wang W, Whittaker D, Wilson DM, Yao Y

R_g^Guinier	7.0	nm
D_max	27.0	nm

SASDP86 – SARS-CoV-2 non-structural protein 8 (nsp8, tetramer) in 250 mM NaCl buffer

Sample:	Replicase polyprotein 1a (Non-structural protein 8, SARS-CoV-2) tetramer, 88 kDa Severe acute respiratory … protein
Buffer:	20 mM HEPES pH 7.4, 250 mM NaCl, pH: 7.4
Experiment:	SANS data collected at BL01-Small Angle Neutron Scattering, China Spallation Neutron Source on 2021 Jul 19

Multiscale characterization reveals oligomerization dependent phase separation of primer-independent RNA polymerase nsp8 from SARS-CoV-2. Commun Biol 5(1):925 (2022)
...Wang H, Liu J

R_g^Guinier	6.3	nm
D_max	24.0	nm

SASDB96 – Compound 1:BRD4 (1:1)

Sample:	Bromodomain-containing protein 4 monomer, 56 kDa Homo sapiens protein
Buffer:	20mM Hepes, 100mM NaCl, 1mM Tris(2-carboxyethyl)phosphine hydrochloride, pH: 7.4
Experiment:	SAXS data collected at BM29, ESRF on 2014 Sep 12

Potent and selective bivalent inhibitors of BET bromodomains. Nat Chem Biol 12(12):1097-1104 (2016)
...Wang W, Whittaker D, Wilson DM, Yao Y

R_g^Guinier	6.2	nm
D_max	27.5	nm

SASDP96 – SARS-CoV-2 non-structural protein 8 (nsp8, tetramer) in 500 mM NaCl buffer

Sample:	Replicase polyprotein 1a (Non-structural protein 8, SARS-CoV-2) tetramer, 88 kDa Severe acute respiratory … protein
Buffer:	20 mM HEPES pH 7.4, 500 mM NaCl, pH: 7.4
Experiment:	SANS data collected at BL01-Small Angle Neutron Scattering, China Spallation Neutron Source on 2021 Jul 19

Multiscale characterization reveals oligomerization dependent phase separation of primer-independent RNA polymerase nsp8 from SARS-CoV-2. Commun Biol 5(1):925 (2022)
...Wang H, Liu J

R_g^Guinier	5.2	nm
D_max	18.0	nm

SASDBA6 – Compound 1:BRD4 (2:1)

Sample:	Bromodomain-containing protein 4 monomer, 56 kDa Homo sapiens protein
Buffer:	20mM Hepes, 100mM NaCl, 1mM Tris(2-carboxyethyl)phosphine hydrochloride, pH: 7.4
Experiment:	SAXS data collected at BM29, ESRF on 2014 Sep 12

Potent and selective bivalent inhibitors of BET bromodomains. Nat Chem Biol 12(12):1097-1104 (2016)
...Wang W, Whittaker D, Wilson DM, Yao Y

R_g^Guinier	6.3	nm
D_max	24.5	nm

SASDPA6 – SARS-CoV-2 non-structural protein 8 (nsp8, tetramer) in 1000 mM NaCl buffer

Sample:	Replicase polyprotein 1a (Non-structural protein 8, SARS-CoV-2) tetramer, 88 kDa Severe acute respiratory … protein
Buffer:	20 mM HEPES pH 7.4, 1000 mM NaCl, pH: 7.4
Experiment:	SANS data collected at BL01-Small Angle Neutron Scattering, China Spallation Neutron Source on 2021 Jul 19

Multiscale characterization reveals oligomerization dependent phase separation of primer-independent RNA polymerase nsp8 from SARS-CoV-2. Commun Biol 5(1):925 (2022)
...Wang H, Liu J

R_g^Guinier	4.8	nm
D_max	16.0	nm

SASDBB6 – Compound 6:BRD4 (1:1)

Sample:	Bromodomain-containing protein 4 monomer, 56 kDa Homo sapiens protein
Buffer:	20mM Hepes, 100mM NaCl, 1mM Tris(2-carboxyethyl)phosphine hydrochloride, pH: 7.4
Experiment:	SAXS data collected at BM29, ESRF on 2015 Feb 8

Potent and selective bivalent inhibitors of BET bromodomains. Nat Chem Biol 12(12):1097-1104 (2016)
...Wang W, Whittaker D, Wilson DM, Yao Y

R_g^Guinier	5.1	nm
D_max	24.3	nm

SASDBC6 – Compound 6:BRD4 (2:1)

Sample:	Bromodomain-containing protein 4 monomer, 56 kDa Homo sapiens protein
Buffer:	20mM Hepes, 100mM NaCl, 1mM Tris(2-carboxyethyl)phosphine hydrochloride, pH: 7.4
Experiment:	SAXS data collected at BM29, ESRF on 2015 Feb 8

Potent and selective bivalent inhibitors of BET bromodomains. Nat Chem Biol 12(12):1097-1104 (2016)
...Wang W, Whittaker D, Wilson DM, Yao Y

R_g^Guinier	4.4	nm
D_max	17.3	nm

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